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Phytother Res ; 35(8): 4388-4400, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-33957004

RESUMO

The efficacy, safety, and utility of Nigella sativa seeds oil as a complementary treatment for hypertension, glucose control, and lipid metabolism were evaluated. Hypertensive patients in the intervention (n = 26) and placebo (n = 29) groups received 2.5 ml of N. sativa seeds oil and sunflower oil twice daily for 8 weeks, respectively. The levels of systolic and diastolic blood pressure (SBP, DBP), blood lipid profile, and fasting blood sugar (FBS), at different stages of the treatment period (0, 3, 6, 8 weeks), and malondialdehyde (MDA) and glutathione reductase (GR), at the baseline and end of the study, were assessed. SBP level in the intervention group was significantly reduced, compared with the baseline values (p < .001) and the placebo group (p < .05). A significant decline was observed in the levels of DBP, total cholesterols, and low density lipoprotein (LDL) (p < .000), MDA, and FBS (p < .001); also, a significant increase was observed in the levels of high density lipoprotein (HDL) and GR (p < .001). The use of N. sativa seeds oil as an adjunct to common medications exhibited additional antihypertensive effects as well as beneficial effects on glucose control and lipid metabolism in hypertensive patients with no renal, hepatic, and patient-reported adverse events.


Assuntos
Doenças Cardiovasculares , Fatores de Risco de Doenças Cardíacas , Hipertensão , Nigella sativa , Óleos de Plantas/farmacologia , Anti-Hipertensivos/farmacologia , Doenças Cardiovasculares/prevenção & controle , Método Duplo-Cego , Humanos , Hipertensão/tratamento farmacológico , Nigella sativa/química , Fatores de Risco , Sementes/química
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