[Cytological and histological parallels in atypical colposcopic findings]. / Tsitologichni i khistologichni paraleli pri atipichni kolposkopski nakhodki.

The aim of the present study was to analyse the cytological and histological equivalents in 112 patients with atypical colposcopical findings. The results showed the follow distribution of the findings: for cytological examination in 66 of the patients-I gr. PAP, in 32-II gr. PAP, in 6 III-A gr. PAP, in 1-III-B gr. PAP, in 4-IV gr. PAP and in 3-V gr. PAP. The histological study of the obtained target biopsies established: 7 cases with normal epithelium, 82 with different findings of abnormal epithelium with or without nonspecific and specific inflammatory changes; 18 cases with dysplasia from I to III degrees, 2 cases with CIS and 3 with invasive cancer. The degree of correlation of the different findings, as well as the possible causes for hypo and hyperdiagnostic assessments are discussed.

[A parallel comparison between cytological and cervicographic screening in early pregnancy]. / Sravnitelen paralel mezhdu tsitologichniia i tservikografskiia skrining pri nachalna bremennost.

The aim of this study is to compare the diagnostic possibilities of cytologic and cervicographic screening of the cervix uterus in patients with early pregnancy. Fifty-four patients between the ages of 20 and 37 were examined cytologically and cervicographically in a prospective screening study. The dependability of each of the diagnostic tests was measured histologically (with the patient's approval) using punch biopsy under colposcopic control. The histologic results showed the presence of CIN in 9 women (16.7%), 8 of them with CIN I and one with CIN III. The rest of examined patients (45) had normal of various inflammatory findings. The analysis of the obtained results confirm a statistically significant difference between the two diagnostic, screening methods. The cervicographic examination is considerably more sensitive in finding CIN-44.4% compared to 22.2% of the cytology. Whereas the cytological method has a higher specificity as a test in determining the healthy patients-91.1% versus 51.2% of the cervicography. 12 or 22.2% of the cervicograms were technically defective.

[The use of the Bethesda-terminology cytological system in clinical practice. A pilot study]. / Prilozhenie na Betezda terminologichnata tsitologichna sistema v klinichnata praktika. Pilotno prouchvane.

The aim of the present study is to summarize the one-year experience in applying the Bethesda terminological system (BTS) for assessment of cervical cytology. The study was based on 164 women, aged from 18 to 45, of which 98 with early pregnancy and 66 not pregnant. The materials for cytological examination were prepared by classical techniques and then coloured with hemalaun-eosin. Cytological findings were interpreted according to the revised BTS (1991), and an assessment of the adequacy of smears, possible infectious and reactive changes was made. Intraepithelial lesions were classified in two categories--low and high grade lesions. The advantages and shortcomings of the proposed new terminological, cytological classification system for assessment of the uterine cervix are discussed.

[The colposcopic, cytological and histological changes in the cervix uteri of women under 20 with a first pregnancy]. / Kolposkopski, tsitologichni i khistologichni promeni na matochnata shiika pri zheni pod 20 godini s nachalna bremennost.

The study includes 42 pregnant women chosen at random under the age of 20, in their first trimester presented for voluntary termination of pregnancy. Colposcopic, cytologic and histological test was performed. Chronic, often acute, non-specific inflammatory changes were observed, probably connected with early sex life. The establishing of a histologically atypical results in 33.3% of the cases as well as the observation of 21.7% falsely negative results from the colposcopic study support the theory of pregnancy as a factor causing complication for diagnosis. The relatively low sensitivity of the cytology method and 16.7% false negative results none the less the existence of high specificity (100%) is due to coexistence of low-stage dysplasia (I and II stage) and chronic non-specific inflammatory processes and the early, pilot character of the research.

[The antenatal diagnosis of the sex of the fetus by the cytological determination of sex chromatin]. / Antenatalna diagnoza pol na ploda chrez tsitologichno opredeliane na poloviia khromatin.

Forty women between 17 and 23 weeks' gestation were included in the study, whose interruption of pregnancy was performed by medical and social indications. The method of Aburel-Atanasov was used as in 10 ml of the removed amniotic fluid sex chromatin was examined cytologically on cellular smears. Staining and determination of sex chromatin was made by the method of Dokumov. The fetus of male sex, when there was no sex chromatin, but the sex was female, when it was present in various percentage of cells. The genuine sex of the fetus was determined after interruption of pregnancy. Coincidence of cytological and genuine sex of the fetus was found in 36 cases (92.31%), but the sex was determined not exactly in 3 cases (7.69%). There was no sufficient material for preparation of high-grade cytological smears in one case. 14 out of 40 fetuses were of female sex (with sex chromatin in 28.57% of cells on the average) and 25 of male sex. The significance and advantages of the method in comparison with other methods for determination of fetal sex at the same term of pregnancy are discussed.

[A comparison of cytological and histological studies on women with a colposcopically atypical cervix uteri]. / Sravnenie na tsitologichni i khistologichni izsledvaniia pri zheni s kolposkopski atipizum na matochnata shiika.

The study was made on 62 at random chosen women between 16 and 71 years of age with atypical colposcopic findings, on whom cytological and histological studies were performed. Histological atypical epithelium was found in 36 patients. 3 out of 36 women had invasive carcinoma, 8--carcinoma in situ, but dysplasia of I to III degree was established in 25 women. The comparison of cytological and histological findings show a high degree of correlation.