The importance of integrated therapies on cancer: Silibinin, an old and new molecule.

In the landscape of cancer treatments, the efficacy of coadjuvant molecules remains a focus of attention for clinical research with the aim of reducing toxicity and achieving better outcomes. Most of the pathogenetic processes causing tumour development, neoplastic progression, ageing, and increased toxicity involve inflammation. Inflammatory mechanisms can progress through a variety of molecular patterns. As is well known, the ageing process is determined by pathological pathways very similar and often parallel to those that cause cancer development. Among these complex mechanisms, inflammation is currently much studied and is often referred to in the geriatric field as 'inflammaging'. In this context, treatments active in the management of inflammatory mechanisms could play a role as adjuvants to standard therapies. Among these emerging molecules, Silibinin has demonstrated its anti-inflammatory properties in different neoplastic types, also in combination with chemotherapeutic agents. Moreover, this molecule could represent a breakthrough in the management of age-related processes. Thus, Silibinin could be a valuable adjuvant to reduce drug-related toxicity and increase therapeutic potential. For this reason, the main aim of this review is to collect and analyse data presented in the literature on the use of Silibinin, to better understand the mechanisms of the functioning of this molecule and its possible therapeutic role.

Translational Application of a Neuro-Scientific Multi-Modal Approach Into Forensic Psychiatric Evaluation: Why and How?

A prominent body of literature indicates that insanity evaluations, which are intended to provide influential expert reports for judges to reach a decision "beyond any reasonable doubt," suffer from a low inter-rater reliability. This paper reviews the limitations of the classical approach to insanity evaluation and the criticisms to the introduction of neuro-scientific approach in court. Here, we explain why in our opinion these criticisms, that seriously hamper the translational implementation of neuroscience into the forensic setting, do not survive scientific scrutiny. Moreover, we discuss how the neuro-scientific multimodal approach may improve the inter-rater reliability in insanity evaluation. Critically, neuroscience does not aim to introduce a brain-based concept of insanity. Indeed, criteria for responsibility and insanity are and should remain clinical. Rather, following the falsificationist approach and the convergence of evidence principle, the neuro-scientific multimodal approach is being proposed as a way to improve reliability of insanity evaluation and to mitigate the influence of cognitive biases on the formulation of insanity opinions, with the final aim to reduce errors and controversies.

A multidisciplinary approach to insanity assessment as a way to reduce cognitive biases.

Insanity assessment requires the evaluation of the psychopathological condition that underlies the mens rea. Psychopathological evaluation may be quite challenging due to (i) absence of biomarkers; (ii) low inter-rater reliability; (iii) presence of cognitive bias. This intrinsic low reliability of forensic psychiatric diagnosis does impact on insanity assessment, leading to arbitrary and unjust legal outcomes for the examinee. Thus, strategies to improve the reliability of insanity evaluation are strongly needed. A multidisciplinary approach has been proposed as a way to enrich clinical diagnosis with reliable and biologically founded data, thus minimizing subjectivity, reducing controversies and increasing inter-subject concordance in insanity assessment. By discussing a real case, here we show how the convergence of multiple indices can produce evidence that cannot be denied without introducing logical fallacies. Applying this approach, the forensic discussion will move from the presence/absence of psychopathology to the impact of psychopathology on insanity. This article illustrates how a multidisciplinary evaluation, which integrates neuroscientific methods with the classical insanity assessment, may lead to a more accurate approach in insanity evaluation. Critically, this approach will minimize the impact of cognitive bias on insanity opinion and thus result in an improvement of the whole criminal justice process.

The detection of faked identity using unexpected questions and choice reaction times.

The identification of faked identities, especially within the Internet environment, still remains a challenging issue both for companies and researchers. Recently, however, latency-based lie detection techniques have been developed to evaluate whether the respondent is the real owner of a certain identity. Among the paradigms applied to this purpose, the technique of asking unexpected questions has proved to be useful to differentiate liars from truth-tellers. The aim of the present study was to assess whether a choice reaction times (RT) paradigm, combined with the unexpected question technique, could efficiently detect identity liars. Results demonstrate that the most informative feature in distinguishing liars from truth-tellers is the Inverse Efficiency Score (IES, an index that combines speed and accuracy) to unexpected questions. Moreover, to focus on the predictive power of the technique, machine-learning models were trained and tested, obtaining an out-of-sample classification accuracy of 90%. Overall, these findings indicate that it is possible to detect liars declaring faked identities by asking unexpected questions and measuring RTs and errors, with an accuracy comparable to that of well-established latency-based techniques, such as mouse and keystroke dynamics recording.