Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 14 de 14
Filtrar
Mais filtros










Intervalo de ano de publicação
1.
Transfus Apher Sci ; 57(5): 639-645, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30228046

RESUMO

OBJECTIVE: To assess the effectiveness of apheresis therapy (AT) in treating the clinical manifestations of patients with complicated cryoglobulinemic vasculitis (CV). METHODS: A retrospective cohort study of 159 CV patients attending 22 Italian Centers who underwent at least one AT session between 2005 and 2015. The response to AT was evaluated on the basis of a defined grading system. RESULTS: Peripheral neuropathy was the most frequent clinical condition leading to AT. Therapeutic plasma exchange was used in 70.4% of cases. The outcome of AT was rated very good in 19 cases, good in 64, partial/transient in 40, and absent/not assessable in 36. Life-threatening CV-related emergencies and renal impairment independently correlated with failure to respond to AT. The independent variables associated with an increased risk of death were age at the time of the first AT session, multi-organ life-threatening CV, the presence of renal impairment and failure to respond to AT. The time-dependent probability of surviving until CV-related death in the second year was 84%, with an AHR in patients with absent/not assessable response to AT of 11.25. CONCLUSION: In this study AT is confirmed to be a safe procedure in patients with CV. Early AT should be considered in patients with severe CV, especially in cases with impending renal involvement, in order to prevent irreversible kidney damage. Although its efficacy in patients with multi-organ failure is limited, AT is the only treatment that can rapidly remove circulating cryoglobulins, and should be considered an emergency treatment.


Assuntos
Remoção de Componentes Sanguíneos/métodos , Crioglobulinemia/terapia , Troca Plasmática/métodos , Idoso , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
2.
Clin Exp Rheumatol ; 31(1 Suppl 75): S9-14, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23044040

RESUMO

OBJECTIVES: To study the health-related quality of life (HRQOL) in severe cryoglobulinaemic vasculitis (CV) associated with hepatitis C virus infection (HCV) and to describe the effect of rituximab on HRQOL. METHODS: HRQOL was evaluated with the Medical Outcomes Study Short Form 36 (SF-36). Health Survey questionnaire was submitted to 15 patients with severe CV. SF-36 questionnaire was evaluated at baseline and after rituximab. Physical Health Composite Summary (PCS) and Mental Health Composite Summary (MCS) scores were calculated according to standard protocols, and normalised to healthy controls. SF-36 summary scores were compared with those of HCV positive patients without CV, and other vasculitis published in the literature. European Quality of Life-5 dimensions (EQ5D) scores were also derived. RESULTS: Physical and mental domain scores were all reduced if compared with those of the healthy population, with physical domains being greatly affected. HRQOL of CV was comparable with HRQOL reported for the other small vessel vasculitis. The development of CV in HCV positive patients worsened PCS rather than MCS score. Birmingham Vasculitis Activity Score (BVAS) did not correlate with HRQOL, while the presence of peripheral neuropathy was associated with a worse HRQOL. Early rituximab treatment improved both PCS and MCS scores, with long-term effects. CONCLUSIONS: PCS rather than MCS was affected in HCV positive patients when CV is present. Rituximab improved both physical and mental domains, thus supporting its use before antiviral therapy in severe HCV-related CV. The cost/benefits ratio of a sequential therapy may be supported.


Assuntos
Anticorpos Monoclonais Murinos/uso terapêutico , Linfócitos B/efeitos dos fármacos , Crioglobulinemia/tratamento farmacológico , Nível de Saúde , Fatores Imunológicos/uso terapêutico , Depleção Linfocítica/métodos , Qualidade de Vida , Vasculite/tratamento farmacológico , Adulto , Idoso , Anticorpos Monoclonais Murinos/economia , Linfócitos B/imunologia , Análise Custo-Benefício , Crioglobulinemia/sangue , Crioglobulinemia/economia , Crioglobulinemia/imunologia , Crioglobulinemia/fisiopatologia , Crioglobulinemia/psicologia , Custos de Medicamentos , Feminino , Hepatite C/complicações , Hepatite C/imunologia , Hepatite C/virologia , Humanos , Fatores Imunológicos/economia , Depleção Linfocítica/economia , Masculino , Saúde Mental , Pessoa de Meia-Idade , Anos de Vida Ajustados por Qualidade de Vida , Rituximab , Índice de Gravidade de Doença , Inquéritos e Questionários , Fatores de Tempo , Resultado do Tratamento , Vasculite/sangue , Vasculite/economia , Vasculite/imunologia , Vasculite/fisiopatologia , Vasculite/psicologia
3.
Nephron ; 87(3): 257-62, 2001 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11287761

RESUMO

BACKGROUND: Metabolic acidosis contributes to renal osteodystrophy and together with hyperphosphatemia, hypocalcemia and altered vitamin D metabolism may result in increased levels of intact parathyroid hormone (iPTH) and metastatic calcifications. However, the impact of the correction of metabolic acidosis on iPTH levels and calcium-phosphate metabolism is still controversial. STUDY DESIGN: The effects of the correction of metabolic acidosis on serum concentrations of iPTH, calcium (Ca), phosphate (PO(4)) and alkaline phosphatase were prospectively studied. Twelve uremic patients on maintenance hemodialysis (HD) for 49 months (median; range 6-243 months) with serum bicarbonate levels < or =20 mmol/l were studied before and after 3 months of oral sodium bicarbonate supplementation. Predialysis serum bicarbonate, arterial pH, ionized calcium, plasma sodium, plasma potassium, serum creatinine, hemoglobin, K(t)/V, postdialysis body weight, predialysis systolic and diastolic blood pressure were also evaluated before and after correction. RESULTS: Serum bicarbonate levels and arterial pH increased respectively from 19.3 +/- 0.6 to 24.4 +/- 1.2 mmol/l (p < 0.0001) and 7.34 +/- 0.03 to 7.40 +/- 0.02 (p < 0.001). iPTH levels decreased significantly from 399 +/- 475 to 305 +/- 353 pg/ml (p = 0.026). No changes in total serum Ca, plasma PO(4), serum akaline phosphatase, K(t)/V, serum creatinine, hemoglobin, body weight, predialysis systolic and diastolic blood pressures were observed. iCa decreased significantly. CONCLUSIONS: Our study demonstrates that the correction of metabolic acidosis in chronic HD patients reduces iPTH concentrations in HD patients with secondary hyperparathyroidism possibly by a direct effect on iPTH secretion.


Assuntos
Acidose/sangue , Acidose/terapia , Cálcio/sangue , Hormônio Paratireóideo/sangue , Uremia/sangue , Equilíbrio Ácido-Base , Acidose/etiologia , Adulto , Idoso , Fosfatase Alcalina/sangue , Calcitriol/uso terapêutico , Feminino , Humanos , Hiperparatireoidismo Secundário/complicações , Hiperparatireoidismo Secundário/metabolismo , Masculino , Pessoa de Meia-Idade , Fosfatos/sangue , Estudos Prospectivos , Análise de Regressão , Diálise Renal , Bicarbonato de Sódio/administração & dosagem , Uremia/complicações , Uremia/terapia
4.
Nephrol Dial Transplant ; 16(1): 111-4, 2001 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11209002

RESUMO

BACKGROUND: The effect of the adequacy of dialysis on the response to recombinant human erythropoietin (rHuEpo) therapy is still incompletely understood because of many confounding factors such as iron deficiency, biocompatibility of dialysis membranes, and dialysis modality that can interfere. METHODS: We investigated the relationship between Kt/V and the weekly dose of rHuEpo in 68 stable haemodialysis (HD) patients (age 65+/-15 years) treated with bicarbonate HD and unsubstituted cellulose membranes for 6-343 months (median 67 months). Inclusion criteria were HD for at least 6 months, subcutaneous rHuEpo for at least 4 months, transferrin saturation (TSAT) > or = 20%, serum ferritin > or = 100 ng/ml, and haematocrit (Hct) level targeted to 35% for at least 3 months. Exclusion criteria included HBsAg and HIV positivity, need for blood transfusions or evidence of blood loss in the 3 months before the study, and acute or chronic infections. Hct and haemoglobin (Hb) levels were evaluated weekly for 4 weeks; TSAT, serum ferritin, Kt/V, PCRn, serum albumin (sAlb), and weekly dose of rHuEpo were evaluated at the end of observation. No change in dialysis or therapy prescription was made during the study. RESULTS: The results for the whole group of patients were: Hct 35 +/- 1.2%, Hb 12.1 +/- 0.6 g/dl, TSAT 29 +/- 10%, serum ferritin 204 +/- 98 ng/ml, sAlb 4.1 +/- 0.3 g/dl, Kt/V 1.33 +/-0.19, PCRn 1.11+/- 0.28 g/kg/day, weekly dose of rHuEpo 123 +/- 76 U/kg. Hct did not correlate with Kt/V, whereas rHuEpo dose and Kt/V were inversely correlated (r = -0.49; P < 0.0001). Multiple regression analysis with rHuEpo as dependent variable confirmed Kt/V as the only significant variable (P < 0.002). Division of the patients into two groups according to Kt/V (group A, Kt/V < or = 1.2; group B, Kt/V > or = 1.4), showed no differences in Hct levels between the two groups, while weekly rHuEpo dose was significantly lower in group B than in group A (group B, 86 +/- 33 U/kg; group A, 183 +/- 95 U/kg, P < 0.0001). CONCLUSIONS: In iron-replete HD patients treated with rHuEpo in the maintenance phase, Kt/V exerts a significant sparing effect on rHuEpo requirement independent of the use of biocompatible synthetic membranes. By optimizing rHuEpo responsiveness, an adequate dialysis treatment can contribute to the reduction of the costs of rHuEpo therapy.


Assuntos
Eritropoetina/administração & dosagem , Diálise Renal/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Anemia/sangue , Anemia/tratamento farmacológico , Anemia/etiologia , Materiais Biocompatíveis , Relação Dose-Resposta a Droga , Feminino , Hematócrito , Humanos , Falência Renal Crônica/complicações , Falência Renal Crônica/fisiopatologia , Falência Renal Crônica/terapia , Rins Artificiais , Masculino , Pessoa de Meia-Idade , Proteínas Recombinantes , Ureia/metabolismo
5.
Am J Kidney Dis ; 36(6): 1089-109, 2000 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-11096032

RESUMO

Cholesterol crystal embolism, sometimes separately designated atheroembolism, is an increasing and still underdiagnosed cause of renal dysfunction antemortem in elderly patients. Renal cholesterol crystal embolization, also known as atheroembolic renal disease, is caused by showers of cholesterol crystals from an atherosclerotic aorta that occlude small renal arteries. Although cholesterol crystal embolization can occur spontaneously, it is increasingly recognized as an iatrogenic complication from an invasive vascular procedure, such as manipulation of the aorta during angiography or vascular surgery, and after anticoagulant and fibrinolytic therapy. Cholesterol crystal embolism may give rise to different degrees of renal impairment. Some patients show only a moderate loss of renal function; in others, severe renal failure requiring dialysis ensues. An acute scenario with abrupt and sudden onset of renal failure may be observed. More frequently, a progressive loss of renal function occurs over weeks. A third clinical form of renal atheroemboli has been described, presenting as chronic, stable, and asymptomatic renal insufficiency. The renal outcome may be variable; some patients deteriorate or remain on dialysis, some improve, and some remain with chronic renal impairment. In addition to the kidneys, atheroembolization may involve the skin, gastrointestinal system, and central nervous system. Renal atheroembolic disease is a difficult and controversial diagnosis for the protean extrarenal manifestations of the disease. In the past, the diagnosis was often made postmortem. However, in the last decade, awareness of atheroembolic renal disease has improved, enabling us to make a correct premortem diagnosis in a number of patients. Correct diagnosis requires the clinician to be alert to the possibility. The typical patient is a white man aged older than 60 years with a baseline history of hypertension, smoking, and arterial disease. The presence of a classic triad characterized by a precipitating event, acute or subacute renal failure, and peripheral cholesterol crystal embolization strongly suggests the diagnosis. The confirmatory diagnosis can be made by means of biopsy of the target organs, including kidneys, skin, and the gastrointestinal system. Thus, Cinderella and her shoe now can be well matched during life. Patients with renal atheroemboli have a dismal outlook. A specific treatment is lacking. However, it is an important diagnosis to make because it may save the patient from inappropriate treatment. Finally, recent data suggest that an aggressive therapeutic approach with patient-tailored supportive measures may be associated with a favorable clinical outcome.


Assuntos
Embolia de Colesterol/complicações , Nefropatias/etiologia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Doenças da Aorta/complicações , Doenças da Aorta/diagnóstico , Doenças da Aorta/patologia , Arteriosclerose/complicações , Arteriosclerose/diagnóstico , Arteriosclerose/patologia , Biópsia , Embolia de Colesterol/diagnóstico , Embolia de Colesterol/patologia , Feminino , Humanos , Rim/patologia , Nefropatias/diagnóstico , Nefropatias/patologia , Masculino , Pessoa de Meia-Idade , Fatores Sexuais
6.
Arq Gastroenterol ; 35(1): 54-61, 1998.
Artigo em Português | MEDLINE | ID: mdl-9711315

RESUMO

We present the first, probably autocton, case of abdominal angiostrongyliasis in Rio de Janeiro State. The patient presented initially with fever of unknown origin and severe eosinophilia developing acute abdomen due to small bowel perfuration, peritonitis, hepatic necrosis and sepsis. At the laparotomy a segment of small bowel was ressected and a liver biopsy was performed. Histopatology revealed the presence of an intra-arterial nematode, eosinophilic arteritis and granuloma. It is discussed the clinicopathological aspects of this rare and potentially severe disease that has not an established drug treatment since oral anti-helmintics are contra-indicated. The authors emphasize the importance of avoiding indiscriminate use of oral anti-helmintic drugs based only in blood eosinophilia.


Assuntos
Doenças Endêmicas , Infecções por Strongylida/patologia , Infecções por Strongylida/parasitologia , Adulto , Animais , Brasil/epidemiologia , Humanos , Masculino , Infecções por Strongylida/epidemiologia
7.
Nephrol Dial Transplant ; 13(7): 1719-22, 1998 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-9681718

RESUMO

BACKGROUND: Metabolic acidosis in haemodialysis (HD) patients increases whole body protein degradation while the correction of acidosis reduces it. However, the effects of the correction of acidosis on nutrition have not been clearly demonstrated. STUDY DESIGN: In this study we have evaluated the effects of 3 months of correction of metabolic acidosis by oral sodium bicarbonate supplementation on protein catabolic rate (PCRn) and serum albumin concentrations in 12 uraemic patients on maintenance HD for at least 6 months (median 49 months; range 6-243 months). Pre-dialysis serum bicarbonate, arterial pH, serum albumin, total serum proteins, serum creatinine, plasma sodium, haemoglobin, PCRn, Kt/V, and TACurea, were evaluated before and after correction. RESULTS: Serum bicarbonate levels and arterial pH increased respectively from 19.3 +/- 0.6 mmol/l to 24.4 +/- 1.2 mmol/l (P < 0.0001) and 7.34 +/- 0.03 to 7.40 +/- 0.02 (P < 0.0001). Serum albumin increased from 34.9 +/- 2.1 g/l to 37.9 +/- 2.9 g/l (P < 0.01), while PCRn decreased from 1.11 +/- 0.17 g/kg/day to 1.03 +/- 0.17 g/kg/day (P < 0.001). No changes in Kt/V, total serum proteins, serum creatinine, plasma sodium, haemoglobin, body weight, pre dialysis systolic and diastolic blood pressure, and intradialytic weight loss were observed. CONCLUSIONS: Our data demonstrate that correction of metabolic acidosis improves serum albumin concentrations in HD patients. The correction of acidosis induces a decrease in PCRn values, as evaluated by kinetic criteria, suggesting that in the presence of moderate to severe acidosis this parameter does not reflect the real dietary protein intake of the patients probably as a result of increased catabolism of endogenous proteins. The correction of metabolic acidosis should be considered of paramount importance in HD patients.


Assuntos
Acidose/tratamento farmacológico , Acidose/etiologia , Proteínas Alimentares/administração & dosagem , Proteínas Alimentares/metabolismo , Diálise Renal/efeitos adversos , Albumina Sérica/metabolismo , Adulto , Idoso , Bicarbonatos/sangue , Feminino , Humanos , Concentração de Íons de Hidrogênio , Masculino , Pessoa de Meia-Idade , Distúrbios Nutricionais/tratamento farmacológico , Distúrbios Nutricionais/etiologia , Distúrbios Nutricionais/metabolismo , Estado Nutricional , Estudos Prospectivos , Proteínas/metabolismo , Bicarbonato de Sódio/administração & dosagem , Uremia/metabolismo , Uremia/terapia
9.
Rev Paul Med ; 109(5): 217-20, 1991.
Artigo em Português | MEDLINE | ID: mdl-1821066

RESUMO

The author dissected 30 orbital regions and studied the intraorbital fat topography and its anterior expansions, "the baggy eyelids". Surgical considerations of these structures were also made.


Assuntos
Tecido Adiposo/anatomia & histologia , Pálpebras/anatomia & histologia , Órbita/anatomia & histologia , Tecido Adiposo/cirurgia , Adulto , Pálpebras/cirurgia , Feminino , Humanos , Masculino , Órbita/cirurgia , Cirurgia Plástica
12.
Rev. paul. med ; 102(5): 223-5, 1984.
Artigo em Português | LILACS | ID: lil-22717

RESUMO

Os autores apresentam a experiencia na reparacao de assoalho orbitario fraturado utilizando enxerto osseo de tabua externa do osso parietal. Descrevem a tecnica empregada em seis pacientes que foram observados no periodo de 6 meses a 1 ano; analisam os resultados obtidos e discutem as vantagens e desvantagens desta conduta


Assuntos
Humanos , Osso Parietal , Fraturas Orbitárias , Seguimentos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...