Factores clínicos y psicosociales asociados al control de crisis en pacientes con epilepsia mioclónica juvenil / Clinical and psychosocial factors associated with seizure control in patients with juvenile myoclonic epilepsy

Objetivo: Identificar los factores clínicos y psicosociales de una cohorte colombiana de pacientes con epilepsia mioclónica juvenil y su relación con el control de las crisis. Pacientes y métodos: Estudio de cohortes retrospectivo de pacientes mayores de 14 años con diagnóstico de epilepsia mioclónica juvenil, con 12 meses de seguimiento en un programa de epilepsia, donde se evaluaron las características sociodemográficas y clínicas y la encuesta para la valoración de los condicionantes de recaída. Se realizó un análisis bivariado y multivariado mediante regresión logística binaria. Resultados: Registros de historias clínicas entre noviembre de 2014 y diciembre de 2016, donde se evaluó a 145 pacientes con diagnóstico de epilepsia mioclónica juvenil que cumplieron los criterios de selección. Los factores asociados al control de las crisis fueron: plan de salud, accesibilidad, actitudes personales, antecedente de consumo, farmacorresistencia y número mensual de crisis; de éstos, plan de salud, actitudes personales y número mensual de crisis persisten con significación estadística tras el análisis de regresión logística. Conclusión: Los factores psicosociales no sólo influyen en el control de las crisis sino que, sumados con algunos factores clínicos, podrían explicar el 40% del control de las crisis en los pacientes con epilepsia mioclónica juvenil y, por ende, influir en su pronóstico a largo plazo

Aim: To identify the clinical and psychosocial factors of a Colombian cohort of patients with juvenile myoclonic epilepsy and its relation to crisis control. Patients and methods: retrospective cohort study of patients over 14 years of age with a diagnosis of juvenile myoclonic epilepsy, with 12 months of follow-up in an epilepsy program, where the sociodemographic and clinical characteristics and the survey for the assessment of relapse conditioners. A bivariate and multivariate analysis was performed using binary logistic regression. Results: Clinical records between November 2014 and December 2016 where 145 patients with a diagnosis of juvenile myoclonic epilepsy who met the selection criteria were evaluated. The factors associated with crisis control were: health plan, accessibility, personal attitudes, history of consumption, drug resistance, and crisis number per month; of these, health plans, personal attitudes, and crisis number per month persist with statistical significance after the logistic regression analysis. Conclusion: Psychosocial factors not only impact on crisis control, added to clinical factors explain 40% of crisis control in patients with juvenile myoclonic epilepsy and therefore affect their long-term prognosis

The Influence of EEG References on the Analysis of Spatio-Temporal Interrelation Patterns.

The characterization of the functional network of the brain dynamics has become a prominent tool to illuminate novel aspects of brain functioning. Due to its excellent time resolution, such research is oftentimes based on electroencephalographic recordings (EEG). However, a particular EEG-reference might cause crucial distortions of the spatiotemporal interrelation pattern and may induce spurious correlations as well as diminish genuine interrelations originally present in the dataset. Here we investigate in which manner correlation patterns are affected by a chosen EEG reference. To this end we evaluate the influence of 7 popular reference schemes on artificial recordings derived from well controlled numerical test frameworks. In this respect we are not only interested in the deformation of spatial interrelations, but we test additionally in which way the time evolution of the functional network, estimated via some bi-variate interrelation measures, gets distorted. It turns out that the median reference as well as the global average show the best performance in most situations considered in the present study. However, if a collective brain dynamics is present, where most of the signals get correlated, these schemes may also cause crucial deformations of the functional network, such that the parallel use of different reference schemes seems advisable.