Blinatumomab como puente al transplante en leucemia linfoblástica aguda refractaria con cromosoma Filadelfia negativo: a propósito de un caso / Blinatumomab as a bridge to trasplantation in refractory Philadelphia chromosome negative b-cell acute lymphoblastic leukemia: a case report

Blinatumomab es el primer anticuerpo biespecífico para células T que ha mostrado eficacia para conseguir enfermedad mínima residual negativa en pacientes con leucemia linfoblástica aguda B recidivante o refractaria tras la quimioterapia convencional. Sin embargo, existe escasa evidencia en cuanto a su utilización off label como optimizador de la remisión citológica previa al trasplante de progenitores hematopoyéticos (TPH). Se expone el caso de un paciente que se sometió en condiciones óptimas a TPH alogénico tras un único ciclo de blinatumomab, describiendo el manejo de los efectos adversos presentados y los resultados obtenidos

Blinatumomab is a first class bispecific T-cell engager that has been shown to achieve negative minimal residual disease in patients with relapsed or refractory pre-B acute lymphoblastic leukemia after conventional chemotherapy. Nevertheless, there is little evidence about its role as an off label enhancer of cytological remission prior to stem cell transplantation (SCT). We describe the case of a patient with an excellent performance status who was allowed to undergo alogenic SCT after a single blinatumomab cycle, as well as the management of adverse events and the observed results

[Blinatumomab as a bridge to trasplantation in refractory Philadelphia chromosome negative b-cell acute lymphoblastic leukemia: a case report]. / Blinatumomab como puente al transplante en leucemia linfoblástica aguda refractaria con cromosoma Filadelfia negativo: a propósito de un caso.

Blinatumomab is a first class bispecific T-cell engager that has been shown to achieve negative minimal residual disease in patients with relapsed or refractory pre-B acute lymphoblastic leukemia after conventional chemotherapy. Nevertheless, there is little evidence about its role as an off label enhancer of cytological remission prior to stem cell transplantation (SCT). We describe the case of a patient with an excellent performance status who was allowed to undergo alogenic SCT after a single blinatumomab cycle, as well as the management of adverse events and the observed results.