[The mechanisms of the disordered regulation of hematopoiesis in the late periods after the administration of cytostatic preparations]. / Mekhanizmy narusheniia reguliatsii krovetvorenii v otdalennye sroki posle vvedeniia tsitostaticheskikh preparatov.

It was demonstrated on an experimental model of cytostatic disease induced by a course of injections (1/10 LD50 for 10 days) of antineoplastic agents with various mechanism of action (doxorubicin, vinblastine, cyclophosphamide) that persistent (for 6 months) disorganization of the morphological composition of the thymus and other lymphoid organs is attended by inhibition of the functional activity of the T-cells of the immunity system. It is suggested that the weakened control (on the part of the thymus) due to the effect of the cytostatics may lead to disorders of the processes of proliferation and differentiation of the hematopoietic cells and impairment of the bone marrow morphological composition in late-term periods after cytostatic treatment.

[Long-term consequences of the damaging effect of cytostatic drugs on hematopoiesis and lymphoid tissue]. / Problemy otdalennykh posledstvii povrezhdaiushchego deistviia tsitostaticheskikh preparatov na krovetvorenie i limfoidnuiu tkan'.

The evidence on the changes detectable in remote periods (at 1, 3, and 6 months) is presented. It shows that the quantitative and functional defects are retained in the hemopoietic and lymphoid tissues within 3-6 months after exposure to the effects of various cytostatic agents. These defects may be corrected by means of immunomodulators.

[Experimental study of late effects of the damaging action of doxorubicin on the lymphoid tissue]. / Otdalennye éffekty povrezhdaiushchego deistviia doksorubitsina na limfoidnuiu tka'n v éksperimente.

It was shown in experiments with CBA/Lac J mice that both a single use of doxorubicin (MID) and its use during a treatment course (1/10 LD50.10) induced impairment of the morphological composition of the central and peripheral lymphoid organs along with changes in the functional activity of separate cell populations of the immune system which persisted over a prolonged period up to 3 months. The course use of the drug resulted in a significant decrease in the proliferative response of the splenocytes to the polyclonal T- and B-cell mitogens in 1 month, which was followed by inhibition of interleukin-2 production. On the contrary, 1 month later, the single administration of the cytostatic induced activation of the LPS-responding cell populations and an increase in production of the growth factor in the culture of T-lymphocytes.

[Functional activity of the splenic cells in the late periods after the administration of antitumor preparations with various mechanisms of action]. / Funktsional'naia aktivnost' kletok selezenki v otdalennye sroki posle vvedeniia protivoopukholevykh preparatov s razlichnym mekhanizmom deistviia.

In experiments on CBA/Lac J mice it was found that the course administration of adriamycin (0.95 mg/kg), vinblastine (0.24 mg/kg) and cyclophosphan (27 mg/kg) in 1/10 LD50.10 causes persistent disturbances of the functional activity of the lymphoid tissue manifesting by inhibition of the proliferative response of the spleen lymphocytes to T- and B-cell mitogens one month and to a lesser extent three months after cytostatic action. The lymphotropic effect of adriamycin is due to the predominant damage of the functional activity of T-lymphocytes. Vinblastin suppresses T- and B-cell link of the immunity system and the inhibitory effect of cyclophosphan is directed mainly to B-cell population.