Neuropsychological Impairment in School-Aged Children Born to Mothers With Gestational Diabetes.

The aim of this study was to determine whether school-aged children born to mothers with gestational diabetes show delays in their neuropsychological development. Several key neuropsychological characteristics of 32 children aged 7 to 9 years born to mothers with gestational diabetes were examined by comparing their performance on cognitive tasks to that of 28 children aged 8 to 10 years whose mothers had glucose levels within normal limits during pregnancy. The gestational diabetes group showed low performance on graphic, spatial, and bimanual skills and a higher presence of soft neurologic signs. Lower scores for general intellectual level and the working memory index were also evident. Our results suggest that gestational diabetes is associated with mild cognitive impairment.

Effect of chronic iron deficiency on neuropsychological domains in infants.

The aim of this study was to assess the effects of chronic iron deficiency on neuropsychological traits in infants. We established the nutritional iron status and assessed the neuropsychological characteristics of 58 Mexican 14- to 18-month-old infants. The Bayley Scales of Infant Development, preschool language scales and an environmental sound perception task designed expressly for the study, were used. The infants' mothers were asked to fill out 2 questionnaires concerning their child's sociodemographic background. Six different neuropsychological domains were analyzed. Results showed that the chronic iron deficiency group did show significantly lower scores on language, environmental sound perception, and motor measures, when compared with infants with normal nutritional iron status at 6 and 14 to 18 months. Our conclusion is that the development of language and motor skills and environmental sound perception appeared to be sensitive to the effects of chronic iron deficiency in infants.

Event-related brain potentials in reading disabled children during an inverse serial digit detection task.

It has been reported that limitations in different components of working memory could underlie reading disabilities. In addition, reading-disabled (RD) children seem to perform worse when digit name processing is required. With the purpose to explore further these assumptions one inverse serial digit detection task was evaluated using event-related brain potentials in fifteen 8-year-old RD children and a control group (CG). CG obtained significantly more correct responses than RD, but had similar reaction times. The experimental task performance significantly correlated with the performance on reading tests. Difference event-related potentials showed a voltage component peaking at 160 ms over frontocentral leads (P160d) that reached significantly higher amplitude in RD group, and was interpreted as an index of the amount of neural resources involved in visual working memory load. The amplitude of P160d significantly correlated with reading speed, the backward digit span and with the experimental task performance. Present results point out that highly demanding working memory tasks reveal behavioral and electrophysiological differences in RD children with respect to healthy controls.

Syntactic processing in Turner's syndrome.

A significant controversy concerning language development in Turner's syndrome has been found. Whereas some authors have observed that girls with Turner's syndrome maintain their verbal abilities intact, others have reported significant differences in Wechsler Verbal IQ when compared with normal controls. However, little has been studied about the linguistic characteristics of these patients when using tests to evaluate different linguistic levels. With the aim of assessing syntactic processes, 15 patients with Turner's syndrome (aged 8 to 19 years) were compared with 15 healthy girls, matched by age, Wechsler Full-Scale IQ range, type of school (private or public), and school grade. A syntactic processing battery including 11 different subtests was developed. Compared with controls, the participants with Turner's syndrome obtained a fewer number of correct answers in most of the subtests and shorter latencies in some of them. We concluded that the subjects with Turner's syndrome have difficulties in using syntactic structures. It is suggested that some of these language difficulties are related to disturbances in using spatial-language relationships.