RESUMO
Breakthrough cancer pain (BCP) is common in patients with cancer, causing a negative impairment in quality of life. Recent diagnostic criteria allow for differentiation of background chronic pain and BCP, for which proportion of unpredictable episodes is very high. Five characteristics define BCP: rapid onset, high intensity, maximum intensity (minutes), mean duration 30 min, and unpredictable onset. Fentanyl is a synthetic opioid characterized by rapid absorption and start of the analgesic effects. In addition to comparing some of the marked differences between the four pharmaceutical forms of fentanyl marketed in Spain, this paper discusses the data collected in a comprehensive clinical trial program with fentanyl pectin nasal spray (FPNS), a formulation that takes advantage of the intranasal route and the PecSys™ technology. The FPNS formulation achieves analgesic action 5 min after application and significant pain relief at 10 min. FPNS, therefore, has key features to be an optimal treatment for BCP.
Assuntos
Analgésicos Opioides/uso terapêutico , Dor Irruptiva/tratamento farmacológico , Fentanila/uso terapêutico , Neoplasias/fisiopatologia , Administração Intranasal , Analgésicos Opioides/administração & dosagem , Dor Irruptiva/fisiopatologia , Fentanila/administração & dosagem , Humanos , Sprays NasaisRESUMO
We analyzed the sensitivity and specificity of mouse peritoneal macrophages (MPM) for the diagnosis of infection by Chlamydia trachomatis. Fifty seven samples were studied, 25 of them were from cervix and 32 were from bronchial aspiration, resulting 29 positive by immunofluorescence in McCoy cells and only 16 in MPM. The sensitivity and specificity for MPM were 55% and 96% respectively. We concluded that McCoy cells are the election cells for the diagnosis of Chlamydia infection. However, the MPM can be useful in the recuperation of this microorganism, if no other method is available.