[Factors that determine the intention to use telemedicine in a healthcare organisation]. / Determinantes de la intención de uso de la telemedicina en una organización sanitaria.

INTRODUCTION: There are numerous factors and barriers that hinder the use of telemedicine, among which some aspects of the organisation stand out. Thus, it would be interesting to determine its intention to use it in a health institution. The objective of this paper was to identify the factors that influence the intent to use telemedicine by the group of professionals of the Andalusian Health Service and the type of professionals based on the use and expectations of (information and communications technology (ICT). METHODS: A specific questionnaire was designed based on an extended Model of Technological Acceptance that was distributed to a sample of 2,847 professionals of all the categories of this institution. A univariate analysis, exploratory factor analysis and logistic regression were carried out to determine those explanatory variables that are related to the use of telemedicine. RESULTS: A total of 424 responses were obtained. The study determined that the institution's support, perceived usefulness and ease of use (P<.05) were factors that influence the use of telemedicine. The support of the workers and the technological profile of the professionals (P<.05) were significant. CONCLUSIONS: Due to there being a high number of factors in health services, it is possible to find differences between the explanatory models in each specific organisation. For this reason, studies need to be carried out before the implantation and use of telemedicine systems in order to identify which of the possible variables influence favourable adoption as a prerequisite for the generalised use of telemedicine.

BIK/NBK gene as potential marker of prognostic and therapeutic target in breast cancer patients

PURPOSE: The purpose of this study is to determine the association between the BIK/NBK gene expression and estrogen receptor alpha expression. MATERIALS AND METHODS: We determined the association of BIK/NBK gene expression by real time quantitative reverse transcription polymerase chain reaction and estrogen receptor alpha expression by immunohistochemistry in samples of breast cancer tissue. RESULTS: We found a statistically significant correlation of BIK/NBK gene expression with the estrogen receptor alpha expression (ρ = 0.751, p = 0.004). For verify differences of BIK/NBK gene expression among ERα+ and ERα- breast cancer tissues, Mann-Whitney U test was performed, obtaining significant differences. CONCLUSIONS: BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients according to the estrogen receptor alpha expression (AU)

Incidence and characteristics of lymphoid malignancies in untreated myelodysplastic syndromes.

We have analyzed 1,198 patients with untreated myelodysplastic syndromes (MDS) with two main objectives: (1) to determine the prevalence of lymphoid malignancies (LM) in MDS patients; and (2) to ascertain whether there is some relationship between the MDS subtype and the LM type. In fourteen of 1,198 primary MDS patients (1%) (4 with refractory anemia, 3 with refractory anemia with ring sideroblasts, 2 with refractory anemia with excess of blasts and 5 with chronic myelomonocytic leukemia) a LM was detected. In all cases, the LM was of the B-cell type: 6 cases of chronic lymphocytic leukemia, 5 cases of lymphoplasmacytoid lymphoma, and 3 cases of multiple myeloma. B-cell malignancy did not prevail in any MDS subtype and no correlation was observed between the different varieties of both diseases. In conclusion, in this large series, 1% of the untreated patients with MDS had B-cell malignancy, an association that in most cases is likely to be merely coincidental.