[Radiation protective effect of low molecular weight thymus preparations]. / Protivoluchevoe deistvie nizkomolekuliarnykh preparatov vilochkovoi zhelezy.

The antiradiation efficiency of low molecular thymic preparations (vilosen, thymogen) was determined. The therapeutic activity of thymic preparations is due to their influence on basic radiation injury syndromes (hemopoietic, gastrointestinal, immunodepressive). The protective mechanisms and perspectives of thymic preparations using in pathogenic therapy of radiation diseases are discussed.

[The biological effects in animals in relation to the accident at the Chernobyl Atomic Electric Power Station. 9. The morphofunctional indices of the immunocompetent organs in mice]. / Biologicheskie éffekty u zhivotnykh v sviazi s avariei na Chernobyl'skoi AES. Soobshchenie 9. Morfofunktsional'nye pokazateli nekotorykh immunokompetentnykh organov myshei.

The permanent action of small doses of low-intensity radiation on the immune status of 2.5-3.5 month CC57W mice has been investigated. Total doses of internal and external irradiation were about few cGy. The permanent action of low-level radiation on the experimental animals of the first and fourth generations was shown to change spleen and lymph nodes weights and the count of lymphocytes isolated from these organs. Cellularity and DNA synthesis in the lymph-node lymphocytes and their proliferative response to polyclonal mitogens also changed. The alterations in the parameters that characterized T-lymphocyte population were statistically significant.

[The biological effects in animals in relation to the accident at the Chernobyl Atomic Electric Power Station. 10. Cooperative immune reactions in different generations of mice]. / Biologicheskie éffekty u zhivotnykh v sviazi s avariei na Chernobyl'skoi AES. Soobshchenie 10. Kooperativnye immunnye reaktsii u razlichnykh pokolenii myshei.

The immune status of mice has been assessed by the whole complex of data. The permanent action of low-level radiation has been shown to suppress considerably the rate of reactions of the delayed-type hypersensitivity and "graft versus host" disease, as well as NK and specific cytolytic T-lymphocyte activity. The dynamics of accumulation and the levels of antiviral antibodies in the serum, lung and trachea extracts are virtually invariable. The resistance of experimental animals to influenza is lower than that of non-irradiated mice of the same line and age. The data obtained indicate that the immune disturbances revealed are connected not only with the alteration of lymphoid cell populations, but also with the alteration of the immune regulation mechanisms.

[Heteromorphism of chromosome 1, 9 and 16 homologs in persons living in regions differing in the level of longevity]. / Geteromorfizm gomologov khromosom 1, 9, 16 u lits, prozhivaiushchikh v regionakh s razlichnym urovnem dolgoletiia.

Regional and age-related peculiarities of chromosomal polymorphism are established as a result of studies in C-band heteromorphism of chromosomes 1, 9 and 16 in the long-lived subjects, their relatives and population groups of the Abkhaz and Ukrainian Republics. Heteromorphism frequencies of chromosomes 1 and 9 homologs are higher in the Abkhaz as compared with the Ukrainian Republic. Age-related differences as to the degree of expression of chromosome 9 C-band heteromorphism are found: in the Abkhaz Province the frequency of variants with a high heteromorphism degree increases with age, while in the Ukrainian one--with a low heteromorphism degree.

[Polymorphism of heterochromatin regions of chromosomes 1, 9, 16 and Y in long-lived persons and in persons of various ages from 2 areas of the Soviet Union]. / Polimorfizm geterokhromaticheskikh raionov khromosom 1, 9, 16 i Y u dolgozhitelei i lits raznogo vozrasta dvukh regionov Sovetskogo Soiuza.

Variants of the chromosome polymorphism have been studied in long-living individuals and in persons of the population group from the Abkhazian region. This study and a comparative analysis of the data obtained with the data of the analogous studies of 170 persons in the Ukraine have permitted establishing the peculiarities of the distribution of certain chromosome polymorphism variants in long-living individuals.

[Chromosomes. Aging. Longevity]. / Khromosomy. Starenie. Dolgoletie.

Investigations dealing with the characteristics of chromosomal apparatus at late stages of ontogenesis are analyzed. Both structural and functional changes in the chromosomal apparatus are observed in ageing. Some papers indicate to the association of certain variants of chromosomal polymorphism with the longevity "phenomenon".