[LYMPHOCYTES MEMBRANES FATTY ACID SPECTRUM IN PATIENTS WITH CORONARY HEART DISEASE].

Lymphocytes phospholipid membranes fatty acid spectrum was studied in patients with coronary heart disease. The study involved 77 patients aged 45 to 72 years. Significant decrease of the oleic fatty acid relative content was determined, which violates the lymphocytes membranes structure and possibly negatively affect their functioning. The relative content of arachidonic, palmitic and stearic saturated fatty acids composition of lymphocytes lipids increased. The result indicate that in patients with coronary heart disease increasing polyunsaturated fatty acids elongation in lymphocytes. These changes in the lipid blood, lymphocytes state can explain the observed increase in lymphocytes functional activity.

[Postprandial hypotension].

Postprandial hypotension is the independent risk factor of general mortality, coronary disorders and stroke. It is reviewed risk factors, pathogenesis, symptoms, treatment and prognosis of this disease.

[The impact of clopidogrel and aspigrel on fatty acid spectrum of platelet membrane phospholipids in patients with new-onset angina].

The research of more effective unstable angina treatment is still actual despite the definite protocols exist. It was investigated the lipid acids spectrum of platelet membrane phospholipids in patients with new-onset angina and was analyzed the impact of clopidogrel and aspigrel on its changes.

[The lipid acids spectrum of platelet in patients with new-onset and progressive angina].

The coronary thrombosis is the main factor which leads to acute coronary syndrome. The mechanisms of the coronary thrombogenesis are not found out in detail. It was investigated the changes of the lipid acids spectrum of platelet membrane phospholipids in patients with unstable angina.

[The effect of clopidogrel and aspigrel on myocardial ischemia in patients with unstable angina pectoris].

The modern cardiology pays much attention to research of myocardial ischemia, especially painless myocardial ischemia as the problem of sudden coronary death. Findings from the current study suggest that antianginal therapy which includes antiaggregant and anticoagulant is effective because of decreasing general myocardial ischemia and its painless form.

[The role of branched-chain amino acids metabolism in development of cardiovascular diseases and its risk factors].

Branched-chain amino acids play the key role in many metabolism processes in organism generally and in cardiovascular protection. It was discovered its importance in mitochondrial biogenesis, antioxidant and antiaging processes, its antihypertension and antiarrhythmic effects, its role in obesity and diabetes mellitus.

[Effect of clopidogrel and aspigrel on ectopic cardiac activity in patients with unstable angina pectoris].

The coronary circulation dysfunction in patients with unstable angina pectoris causes development of ventricular and supraventricular cardiac rhythm disorders. Findings from the current study suggest that antianginal therapy of patients with acute coronary syndrome which includes antiaggregant and anticoagulant is effective in the treatment of extrasystolic arrhythmias.

[Development mechanisms and prognostic value of myocardial ischemia].

Silent myocardial ischemia (SMI) is a poor prognostic sign of cardiac events development, such as myocardial infarction and sudden cardiac death. This article presents the last decade research findings dedicated exploring mechanisms of SMI development and prognostic value in patients with coronary heart disease.

[Obstructive sleep apnea: connection with cardiovascular diseases and basic methods of diagnostics].

These literatures are analyses about reasons, pathogenesis, and clinical displays obstructive sleep apnea. Mechanisms over of connection are brought sleep obstructive apnea with development of hypertensive, of cardiac arrhythmias, development of metabolic syndrome, obesity, to pulmonary hypertension, write ventricular insufficiency.

[Age-related features of neurohumoral effects of dopamine activity on the cardiovascular system in elderly people].

Determined the decrease in dopamine activity with age, that contributes to the pathogenesis of hypertension, abdominal obesity, the development of left ventricular hypertrophy. The article presents information describing the age-sensitive regulation of the cardiovascular system in elderly people, confirming the influence of the activity of dopamine receptors in the development of age pathology.

[The effects of hypoxia on initiation and progression of cardiovascular disease in patients with chronic obstructive pulmonary disease].

Hypoxia accompanied chronic obstructive pulmonary disease leads to hypercoagulation, vessels' inflammation, imbalance of oxidative and antioxidative systems. These pathological changes cause arterial hypertension, corpulmonale, metabolism disturbance of the whole organism.

[The role of humoral and cellular disturbances immunity in atherosclerosis and acute coronary syndrome].

Violations gumoralis and cellular immunity examine as one of anchormen of pathogenetic mechanisms development of ischemic heart trouble. These literatures over, that testifying to development of disbalance of subpopulations of T- and B-lymphocitis, are brought, and also levels of immunoglobulin for patients with the stable and unstable flow of ischemic heart trouble.

[Impact of arterial stiffness on cardiovascular disease and hypoxia].

We performed an analysis of scientific studies about arterial stiffness impacting on cardiovascular diseases and special mechanisms of its developing. One of these mechanisms is hypoxie endothelial damage. Pulse pressure, aortic pulse wave velocity, the shape of the blood pressure curve, rheography, rheovasography are the methods for determinating arterial stiffness.

[Immunoglobulins of blood serum in patients with stable and unstable angina].

Article is devoted to the study of immunoglobulins (Ig) classes A, G and M in blood serum of patients with stable and unstable clinical course of ischemic heart disease that improve our knowledge about immuneinflammatory process which develops under destabilization of a coronary circulation.

[Metabolism of polyunsaturated fatty acids and its value for a human body].

The article is devoted to the study of metabolism of polynonsaturated fat acids in a human body as antiatherogenous which prevents the development of cardiovascular diseases (ischemic heart disease, hypertension), as well as oncological diseases, a peptic ulcer of the stomach and duodenum.

[Changes of fatty acid spectrum of thrombocyte lipids in patients with a stable and unstable angina].

Ischemic heart desease (IHD) remains actual issue of the current clinical medicine, because, IHD takes a leading position among reasons of death rate of population. Purpose of the study was to find diagnostic features of fat-acid composition of lipid of thrombocytes in patients with stable and unstable course of ischemic heart disease (IHD). 52 patients with an unstable angina pectoris aged 42-65 years and 31 patients with stable angina aged 41-66 years have been observed. Reliable changes in relation of the sum of saturated, unsaturated and poli-unsaturated of fat acids of phosphotides of thrombocytes in patients with unstable course of ischemic heart disease (IHD) have been detected. It improves knowledge about the mechanisms of destabilization of coronal circulation of blood.

[Early and late biomarkers of late myocardium necrosis in patients with acute coronary syndrome].

Cardio-vascular diseases and acute coronary syndrome (ACS) in the first place play the first role in the structure of diseases and mortality of world population. Effective method of diagnostics of ACS consists in detecting early and late biomarkers of myocardium necrosis. The article presents characteristics of such biomarkers indices as myoglobin, cardiotroponins, MB-fractions of creatine phosphokinase, cardio-form of protein, lactate dehydrogenase, aspartate aminotransferase. The authors described in the artcile diseases which are accomponied with increase in the level of cardiotroponins.

[Effect of etmosin on biliary motility disorders in patients with ischemic heart disease]. / Vplyv etmozynu na porushennia motoryky zhovchovyvidnykh shliakhiv u khvorykh na ishemichnu khvorobu sertsia.

We have studied the influence of Etmosin medication on severity of IHD clinical presentations and comprised biliary motility in 162 patients aged 26 to 60. Dynamic echocholecystography (DECG) has been applied. The obtained data suggest using Etmosin in patients with ischemic heart disease and comprised biliary motility makes for normalizing tonus of the Odi sphincter and decreasing the rate of episodes of angina pectoris, although was not found any influence of Etmosin on gall-bladder motility. The use of Etmosin enables in patients with IHD and comprised biliary motility to decrease reflex angina pectoris.

[Effect of biliary dyskinesia on ischemic heart disease progression]. / Vplyv dyskineziï zhovchovyvidnykh shliakhiv na perebih ishemichnoï khvoroby sertsia.

Heart syndrome features associated with pain, the structure of myocardial ischemia and heart rate derangement were studied in patients with ischemic heart disease (IHD) and concomitant biliary dyskinesia (BD). It was established that BD considerably aggravates clinical course of IHD: increase in frequency of pain and painless episodes of myocardial ischemia in patients with stable exertional angina I-II functional classes by NYHA and single supraventricular and ventricular extrasystoles.

[Clinical efficacy of corinfar retard in the treatment of patients with biliary tract dyskinesia]. / Klinichna efektyvnist' korynfaru retardu u likuvanni khvorykh z dyskineziieiu zhovchnovyvidnykh shliakhiv.

Corinfar-Retard efficacy in patients with hypertonic-hyperkinetic type of biliary dyskinesia has been studied. 56 patients aged 26 to 30 had been prescribed Corinfar-Retard in 20 mg per day for 7 days. Dynamic echocholecystography has applied. Decrease in contraction of gall bladder and normalization of tonic contraction of sphincter Ody was found in the patients with previously diagnosed hypertonic-hyperkinetic type of biliary dyskinesia after having been treated with Corinfar-Retard.