RESUMO
Erythrocytes and platelets phospholipid membranes fatty acid spectrum was detected in coronary heart disease and atrial fibrillation patients and in patients with coronary heart disease without atrial fibrillation. 87 patients were investigated. Significant decrease in the arachidonic acid relative content in coronary heart disease patients compared with healthy individuals was related. As well as a significant decrease in the arachidonic acid relative content in coronary heart disease and atrial fibrillation patients compared with coronary heart disease patients without atrial fibrillation was related too. These dates may indicate that decreasing relative content arachidonic acid can be possible pathogenetic link in the development of arrhythmias.
Assuntos
Ácido Araquidônico/análise , Fibrilação Atrial/sangue , Membrana Celular/química , Doença da Artéria Coronariana/sangue , Ácidos Graxos/análise , Fosfolipídeos/análise , Idoso , Idoso de 80 Anos ou mais , Ácido Araquidônico/metabolismo , Fibrilação Atrial/complicações , Fibrilação Atrial/patologia , Plaquetas/química , Plaquetas/metabolismo , Estudos de Casos e Controles , Membrana Celular/metabolismo , Cromatografia Gasosa , Doença da Artéria Coronariana/complicações , Doença da Artéria Coronariana/patologia , Eritrócitos/química , Eritrócitos/metabolismo , Ácidos Graxos/metabolismo , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fosfolipídeos/metabolismoRESUMO
The study involved 65 progressive angina patients (PA) aged 67 to 73 years. Determination of lymphocytes population and subpopulation was performed by monoclonal antibodies. Immunoglobulin G, A, M and circulating immune complexes (CIC) determination in the blood serum was performed by the Mancini method. The results showed that the clopidogrel with aspirin (aspihrel) combination in the basic treatment of PA patients is more effective than the basic treatment that included only clopidogrel, as evidenced by the positive trend of more indicators of immune status of patients.
