RESUMO
We report the presentation and management of 17 cases of Exophiala dermatitidis and Rhodotorula mucilaginosa bloodstream infections caused by a compounded parenteral medication at an oncology clinic. Twelve patients were asymptomatic. All central venous catheters were removed and antifungal therapy, primarily voriconazole, was administered to patients. Three patients died.
Assuntos
Gerenciamento Clínico , Surtos de Doenças , Contaminação de Medicamentos , Fungemia/tratamento farmacológico , Feoifomicose/tratamento farmacológico , Idoso , Instituições de Assistência Ambulatorial , Antifúngicos/uso terapêutico , Infecções Assintomáticas , Exophiala/efeitos dos fármacos , Exophiala/isolamento & purificação , Feminino , Fungemia/mortalidade , Humanos , Hospedeiro Imunocomprometido , Masculino , Pessoa de Meia-Idade , Serviço Hospitalar de Oncologia , Pacientes Ambulatoriais , Feoifomicose/mortalidade , Rhodotorula/efeitos dos fármacos , Rhodotorula/isolamento & purificaçãoRESUMO
Acute infection with Sin Nombre virus has been associated with development of hantavirus cardiopulmonary syndrome (HCPS), a severe cardiopulmonary illness with respiratory failure and shock. We present two cases of Sin Nombre hantavirus infections that did not lead to marked pulmonary complications in two otherwise healthy young adults from Utah and California. Sin Nombre virus causes a wider spectrum of disease severity than has been previously reported.
Assuntos
Infecções por Hantavirus/complicações , Infecções por Hantavirus/diagnóstico , Orthohantavírus/isolamento & purificação , Edema Pulmonar/etiologia , Doença Aguda , Adulto , California , Feminino , Humanos , Masculino , População Rural , Testes Sorológicos , Índice de Gravidade de Doença , UtahRESUMO
Basidiobolus species are filamentous fungi belonging to the order Entomophthorales. Unlike other zygomycetes, Basidiobolus species have been mainly associated with a tropical form of subcutaneous zygomycosis in otherwise healthy individuals. Visceral disease caused by this pathogen is rare, but cases of gastrointestinal infection with Basidiobolus ranarum have been reported worldwide. In many of these reports, the inflammatory disease of the colon has been confused with Crohn's disease. We report the third case of B. ranarum gastrointestinal infection in the United States, which was initially treated as inflammatory bowel disease.
