RESUMO
The study objective was to determine the association between immunosuppressant therapy (IST) adherence and graft failure among pediatric renal transplant recipients (RTRs) using data reported in the United States Renal Data System (USRDS), which contains Medicare prescription claims. RTRs (Assuntos
Ciclosporina/uso terapêutico
, Rejeição de Enxerto/tratamento farmacológico
, Rejeição de Enxerto/epidemiologia
, Imunossupressores/uso terapêutico
, Transplante de Rim/estatística & dados numéricos
, Adesão à Medicação/estatística & dados numéricos
, Adolescente
, Criança
, Prescrições de Medicamentos/estatística & dados numéricos
, Feminino
, Sobrevivência de Enxerto
, Humanos
, Estimativa de Kaplan-Meier
, Masculino
, Medicare/estatística & dados numéricos
, Modelos de Riscos Proporcionais
, Tacrolimo/uso terapêutico
, Estados Unidos/epidemiologia
RESUMO
We report an 11-year-old boy with hypertension and chronic intestinal pseudo-obstruction, which renders him totally dependent on parenteral nutrition and prevents the use of oral medications. Here we report the feasibility of utilizing chronic i.v. enalaprilat and transdermal clonidine on a chronic basis to control hypertension. Over the last 10 months, the patient's hypertension has been well controlled by 1.25 mg i.v. enalaprilat every 8 h and a 0.2-mg clonidine patch every 6 days, with no apparent side-effects. There are no reports of i.v. enalaprilat usage exceeding 3 weeks' duration. Therefore we believe that it is possible to effect reasonable management of chronic hypertension with the use of chronic i.v. enalaprilat and transdermal clonidine therapy.
