[Maternal plasma and amniotic fluid interleukin-6 and tumor necrosis factor-alpha levels in imminent preterm labor]. / Stezenie interleukiny-6 i czynnika martwicy nowotworu-alpha w surowicy krwi i plynie owodniowym ciezarnych z zagrazajacym porodem przedwczesnym.

DESIGN: Our purpose was to investigate the maternal plasma and amniotic fluid interleukin-6 and tumor necrosis factor-alpha levels in women with imminent preterm labour. MATERIAL AND METHODS: The present study was designed to evaluate IL-6 and TNF-alpha levels in 93 pregnant women with threatened preterm labour and 40 women with normal pregnancy. Maternal blood samples were collected by routine forearm venipuncture at admission during routine laboratory tests. Amniotic fluid was collected through hysterectomy during caesarean delivery from women at term but not in labour and by amniotomy or hysterectomy from women with preterm labour. RESULTS: Maternal plasma and amniotic fluid IL-6 and TNF-alpha concentrations were significantly elevated in women with preterm labour (premature rupture of membranes and uterine contractions) compared to gestationally matched, non-labouring controls.

[Maternal plasma and amniotic fluid interleukin-6 levels in imminent preterm labor]. / Stezenie interleukiny-6 w surowicy krwi i plynie owodniowym ciezarnych z zagrazajacym porodem przedwczesnym.

Our purpose was to investigate the maternal plasma and amniotic fluid interleukin-6 levels in women with preterm labour. The present study was designed to evaluate IL-6 levels in 93 pregnant women with threatened preterm labour and 40 normal pregnant. Maternal blood samples were collected by routine forearm venipuncture at admission during routine laboratory tests. Amniotic fluid was collected during hysteretomy during caesarean delivery from women at term but not in labour and by amniotomy or hysteretomy from women with preterm labour. Maternal plasma and amniotic fluid IL-6 concentrations were significantly elevated in women in preterm labour (premature rupture of membranes and uterine contractions) compared to gestationally matched, non-laboring controls.

[Efficacy of amnioinfusion in anhydramnios at term before induction of labor and newborn outcome]. / Wplyw amnioinfuzji przedporodowej na przebieg indukcji porodu i stan noworodka w ciazy z malowodziem.

Oligohydramnios complicates about 0.5-5% of pregnancies and is associated with an increased rate of perinatal morbidity and mortality. Our purpose was determine the effectiveness of amnioinfusion before induction of labour in reducing the incidence of fetal distress in pregnancies with anhydramnios at term. The rate of cesarean sections performed for fetal distress was higher in the control group (57.1%) than in the amnioinfused group (20.3%). Anhydramnios was associated with an increased abnormalities fetal heart rate. Amnioinfusion is effective option for the prevention of fetal distress in anhydramnios at term.

[The role of endothelium in normal pregnancy and pregnancy complicated by preeclampsia]. / Rola sródblonka naczyniowego w ciazy prawidlowej i powiklanej EPH gestoza.

Endothelial cell dysfunction is thought to play a role in preeclampsia and the reduced production by vascular endothelial cells of the antiaggregatory and vasodilatory factors is well documented. The present study was designed to evaluate endothelial cells function in preeclamptic and healthy pregnant subjects. The nitric oxide plasma concentration in women with preeclampsia was significantly lower as compared with normotensive pregnant women. A significant increase in ET concentration was found in preeclamptic women as compared with normal pregnant patients and normal non-pregnant. The plasma concentrations of von Willebrand factor were significantly increased in healthy pregnancy as compared with preeclamptic patients. The results of our study demonstrate a significant endothelial cells damage in preeclamptic patients. Whether these observations contribute to the vascular pathophysiologic features of preeclampsia remains to be proved.

[The role of nitric oxide and blood platelets in pathogenesis of preeclampsia]. / Rola tlenku azotu (NO) i plytek krwi w patogenezie EPH gestozy.

The aim of this study was to evaluate the concentration of nitric oxide and the platelet function in preeclamptic and normal pregnant women. The patients with preeclampsia had new hypertension (diastolic blood pressure consistently > or = 90 mmHg with previously lower readings), new proteinuria and generalized oedema that subsequently regressed after delivery. Blood was collected by routine forearm venipuncture before delivery. The following parameters were evaluated: nitric oxide, beta-TG and PF4. The nitric oxide plasma concentration in women with preeclampsia was significantly lower compared with normotensive pregnant women. beta-TG and PF4 concentrations were significantly increased in patients with preeclampsia. Whether these observations contribute to the vascular pathophysiologic features of preeclampsia remains to be proved.

14C-arginine-rich basic proteins in ascitic fluid of Ehrlich tumor.

With the use of 14C-arginine it is shown that among the ascitic fluid proteins of Ehrlich tumor there appear basic proteins rich in arginine with the content of amino acid about 14%. The amount of these proteins is about 3%. They exhibit great similarity in respect to arginine content, electrophoretic mobility to the arginine rich basic proteins isolated previously from the cytosol of Ehrlich tumor cells.