Clinical efficacy of adapalene (differin(®)) 0.3% gel in Chilean women with cutaneous photoaging.

Skin photoaging is a concern for many patients today, and it is important for dermatologists to evaluate new therapeutic approaches. This 6-month open-label study evaluated the effectiveness and safety of adapalene 0.3% gel in 40 Latin American women with signs of facial photoaging. Assessments at baseline, week 12, and week 24 included clinical severity grading, measurement of transepidermal water loss, hydration, and elasticity (Cutometer MPA 850®), evaluation of general skin tone and number of wrinkles (VISIA(®) Complexion Analysis System), and ultrasonography to measure changes in skin thickness. There were significant improvements in clinical grading of wrinkles (p < 0.01) with a reduction in mean severity score of 40% in forehead wrinkles, 52% in periorbital wrinkles, and 29% in perioral wrinkles. Melanin, transepidermal water loss, and hydration were improved, as were general skin tone and the number of wrinkles (p < 0.05). Measurement of skin thickness showed a non-significant improvement in the epidermis and dermis and a significant decrease of the elastosis band (11.6% at week 12 and 15.1% at week 24). Adapalene was well tolerated overall, although three patients discontinued the study due to skin irritation in the first month. We conclude that adapalene 0.3% gel is a new safe and effective approach to photoaging.

Specific gel-cream as adjuvant to oral isotretinoin improved hydration and prevented TEWL increase--a double-blind, randomized, placebo-controlled study.

BACKGROUND: Hydrating and emollient products are often recommended to patients under isotretinoin therapy to control the most frequent mucocutaneous side effects and to improve adherence to treatment. AIMS: To assess, using noninvasive biophysical tests, the clinical and instrumental effectiveness of a hydrating gel-cream compared with placebo as an adjuvant to isotretinoin for treatment of facial skin in patients with inflammatory acne. METHODS: Prospective, double-blind, randomized study, using MULTI SKIN MC750, on the adjuvant effect of a hydrating gel-cream for acne (active product) vs. a gel-cream without active substances (placebo). Follow-up lasted 3 months. RESULTS: Sixty-six patients were included. Thirty-four were administered the active product, and 32 placebo. Though the number of lesions fell significantly in both groups, the mean number of papules on day 30 was significantly lower in the active product group. The active product group showed a significant increase in hydration, while the placebo group showed a significant increase in transepidermal water loss (TEWL). Seborrhoea decreased significantly in both groups; there were no differences between them. CONCLUSIONS: Compared with placebo, the specific gel-cream with active products as an adjuvant to oral isotretinoin improved hydration, prevented TEWL increase, and reduced inflammatory acne lesions after 30 days.

Probióticos en dermatitis atópica / Probiotics in atopic dermatitis

Los probióticos corresponden a microorganismos vivos, no patógenos, que son beneficiosos para el huésped a través de sus efectos en la microflora intestinal. El uso de probióticos ha sido recientemente explorado como una opción terapéutica en dermatitis atópica (DA). El razonamiento para este enfoque se basa en la evidencia de que la flora intestinal normal (incluyendo a los probióticos) tendría propiedades inmunomoduladoras y jugaría un rol esencial en el desarrollo de la tolerancia inmunológica normal. Se han realizado varios estudios que han mostrado resultados promisorios con el uso de probióticos en DA; sin embargo aún no está definido que efecto tiene el suplemento de probióticos en niños no alérgicos, niños mayores, o con DA más severa (AU)

Probiotics are defined as live non-pathogenic microorganisms that are beneficial to the host by influencing the intestinal microflora.The use of probiotics has recently been explored as a therapeutic option for Atopic Dermatitis (AD). The rationale for this approach is based on the evidence that normal gut flora (including probiotics) may have immunomodulatory properties and may play an essential rol in the development of normal immune tolerance. Several studies have been conducted showing promisory results of the use of probiotics in AD. However, it is still not yet defined the effect of probiotic supplementation on non-allergic children, older children, or patients with more severe AD (AU)