RESUMO
This contribution describes the development of chemoenzymatic one-pot processes, which combine an oxidative rearrangement and a biotransformation catalyzed by an imine reductase (IRED), for the synthesis of highly enantiomerically enriched secondary amines, such as an aryl-substituted pyrrolidine and a benzazepine. The benefits of this chemoenzymatic one-pot approach include high overall conversions (up to >99%), high enantiomeric excesses (up to >99% ee), and a straightforward synthetic approach toward secondary amines without the need to isolate the formed intermediate. For the initial chemical reaction, namely, the oxidative rearrangement, PhI(OAc)2 in methanol is used as a non-natural reagent, whereas the enzymatic step requires only stoichiometric amounts of d-glucose along with catalytic amounts of IRED, glucose dehydrogenase (GDH), and the cofactor NADPH. This methodology, demonstrating the compatibility of a "classic" organic synthesis using a non-natural, highly reactive reagent and a subsequent biocatalytic step, can be applied for different amines as substrates, thus making this concept a versatile tool in synthetic organic chemistry in general and for enantioselective synthesis of heterocyclic secondary amines in particular.
RESUMO
OBJECTIVE: The aim: To analyze the current state of the problem and develop a modern methodology for the correction and prevention of stress disorders in female veterans. PATIENTS AND METHODS: Materials and methods: The following methods were used during the research: theoretical and interdisciplinary analysis, complex, Ñlinical and psychopatho¬logical examination and methods of mathematical and statistical data processing. RESULTS: Results: In the course of our work, it was developed an algorithm for medical and psychological support for women who suffered from results of the fighting includes the following components: monitoring of the psychological and mental state of veteran women; increased psychological care; psychological support for veteran women; psychotherapy; psychoeducation; creation of a re-adaptation atmosphere; formation of a health-centred living style and strengthening of psychosocial resources. CONCLUSION: Conclusions: The complex system of treatment and prevention of stress-social disorders in women veterans should be aimed at decreasing the level of anxiety-depressive symptoms and the excessive nervous and psychological tension; infective re-evaluation of the traumatic experience; building a positive attitude towards the future and creating a new cognitive model of life.
