RESUMO
Because pleural involvement by chronic lymphocytic leukemia (CLL) is virtually impossible to distinguish from inflammatory disorders using cytologic or histopathologic methods, many investigators have relied on immunologic studies of mononuclear cells isolated from lymphocytic pleural effusions to make the distinction. A patient with B-cell CLL is reported in whom pleural involvement was documented using the frozen-section immunoperoxidase technique on a pleural biopsy even though cells isolated from the associated effusion showed only a small polyclonal B-cell population and a predominance of T cells. No other cause for this "reactive" effusion could be identified. The implications of this previously unreported finding of pleural B-cell CLL infiltration associated with a reactive effusion are discussed.
Assuntos
Linfócitos B/imunologia , Leucemia Linfoide/patologia , Pleura/patologia , Derrame Pleural/patologia , Neoplasias Pleurais/patologia , Linfócitos T/imunologia , Biópsia , Feminino , Humanos , Técnicas Imunoenzimáticas , Leucemia Linfoide/complicações , Pessoa de Meia-Idade , Derrame Pleural/etiologia , Neoplasias Pleurais/complicaçõesRESUMO
A patient had Sézary syndrome and lymphocytic lymphoma. Cytoplasmic inclusions within the Sézary cells were demonstrated by histochemistry and electron microscopy to be composed of fetal-type glycogen. Results of tests for the presence of virus were negative. It is suggested that the Sézary cell represents a reversion of metabolic systems to more youthful types. Previously reported differences in diastase reactivity of the PAS-positive cytoplasmic inclusions are probably based on whether the glycogen is in fetal or mature configuration.
Assuntos
Dermatite Esfoliativa/complicações , Linfoma não Hodgkin/complicações , Clorambucila/uso terapêutico , Grânulos Citoplasmáticos/metabolismo , Grânulos Citoplasmáticos/patologia , Grânulos Citoplasmáticos/ultraestrutura , Dermatite Esfoliativa/metabolismo , Dermatite Esfoliativa/patologia , Glicogênio/metabolismo , Humanos , Linfoma não Hodgkin/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Prednisona/uso terapêutico , Síndrome , Vincristina/uso terapêuticoRESUMO
A patient with myelofibrosis, who has produced many red blood cell autoantibodies, is described. Although the patient is phenotypically R1R1 (CDe/CDe), eluates made from his red blood cells have consistently contained what appeared to be anti-E, and more recently another antibody that appeared to be anti-c. In in vitro experiments we have shown that the "anti-E" and "anti-c" can be totally adsorbed by E-negative and c-negative red blood cells, respectively. We conclude that the two antibodies have quite different specificities from those indicated by simple antibody identification studies, and that both are more closely related to the anti-Hr series of antibodies than to anti-E or anti-c.
