RESUMO
Esophageal acid clearance in healthy dogs was evaluated by placing a pH probe in the distal esophagus and determining the number of swallows and time required for esophageal pH to reach 4.0 after injection of a 10 mL bolus of 0.1 N hydrochloric acid. The increase in pH occurred in a stepwise fashion and was associated with esophageal peristalsis as determined by esophageal manometry. The number of swallows required for acid clearance varied from four to 12 with a mean of 8 +/- 1.8. The time required for acid clearance varied from 150 to 480 s with a mean of 285 +/- 75. No significant difference was noted after 0.16 mg/kg of lenperone hydrochloride was given intramuscularly. The esophageal acid clearance test in dogs appears similar to that reported in humans.
Assuntos
Cães/fisiologia , Esôfago/metabolismo , Animais , Esôfago/fisiologia , Concentração de Íons de Hidrogênio , Masculino , Manometria , PeristaltismoRESUMO
Treatment of healthy dogs with the butyrophenone derivative, lenperone hydrochloride, at two different doses significantly decreased gastroesophageal sphincter pressure (GESP). No dose-related effect was identified. Individual variation in the response to lenperone hydrochloride was noted which was consistent on a day-to-day basis. Lenperone hydrochloride is unsuitable for chemical restraint of dogs undergoing esophageal manometry because it decreases GESP and because the magnitude of the decrease varies considerably between dogs.