[Role of the central and peripheral cholinoreceptors in the processes of short-term memory]. / Rol' tsentral'nykh i perifericheskikh kholinoretseptorov v protsessakh kratkosrochnoi pamiati

Short-term memory with blocked cholinoreceptors was studied by the method of deferred reactions in the choice of one of 3--4 feeding troughs in tests staged on 5 dogs and 5 cats. Disturbances of short-term memory were caused by blocking of central m-cholinoreceptors with benactizyne (0.1--0.4 mg/kg). On abolishing peripheral symptoms arising under the effect of chlorpromazine with carbocholine (0.001 mg/kg) the short-term memory disturbances go on persisting. Blocking of peripheral m-cholino-receptors with lachesine (0.01--0.1 mg/kg) does not have any significant effect on the short-term memory. Under the blocking action of pediphen (0.5--2 mg/kg) on the cerebral n-cholinoreceptors the short-term memory improves with reduced memorization capacity.