[Morphofunctional changes in a culture of pancreatic islet cells from newborn piglets as affected by Coxsackie B3 viruses]. / Morfofunktsional'nye izmeneniia v kul'ture ostrovkovykh kletok podzheludochnoi zhelezy novorozhdennykh porosiat pod vliianiem virusov Koksaki B3.

The direct influence of Coxsackie virus B-3 and its selected variants Abent+ and Abent- on the function and structure of neonatal pig pancreatic islet cells in monolayer cultures was studied. The viruses under study possessed cytopathogenic activity and were capable of reproduction. The Abent- variant of Coxsackie virus B-3 possessed the most pronounced cytopathogenic activity. Direct correlation between virus reproduction and insulin concentration in a culture medium was established.

[The mechanism of plaque production by enteroviruses under bentonite overlay. Relationship between plaque production and the dynamics of intracellular virus reproduction and membrane potential of the host cell]. / Mekhanizm bliashkoobrazovaniia enterovirusov pod bentonitovym pokrytiem. Sviaz' bliashkoobrazovaniia s dinamikoi vnutrikletochnogo razmnozheniia virusov i membrannym potentsialom kletki-khoziaina

The association of plaque production under bentonite overlay with the cycle of intracellular reproduction of enteroviruses and the dynamics of the membrane potential of infected cells was studied. It was shown that by the time of termination of the intracellular enterovirus reproduction cycle (4 1/2-5 hours postinfection) bentonite particles were torn away from the cell surface. At the same time the membrane potential of the host cell began to decline progressively. The data obtained explain the character of morphology of virus plaques under bentonite overlay.