1.
RSC Adv
; 10(57): 34938-34942, 2020 Sep 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35514391
RESUMO
An efficient and mild method has been developed for the amination of ß-methoxy amides (γ-lactones) including natural products michelolide, costunolide and parthenolide derivatives by using lithium chloride in good yields. This reaction is applicable to a wide range of substrates with good functional group tolerance. Mechanism studies show that the reactions undergo a LiCl promoted MeOH elimination from the substrates to form the corresponding α,ß-unsaturated intermediates followed by the Michael addition of amines.