Potential roles of Helicobacter pylori treatment, body mass index and waist circumference in the causation of erosive esophagitis: a randomized clinical trial (HEROES-GERD).

BACKGROUND: In recent decades, the prevalence of gastroesophageal reflux disease (GERD) and obesity has been increasing while Helicobacter pylori infection has been decreasing. OBJECTIVE: To evaluate if H. pylori treatment, excess body weight and other anthropometric measurements are associated with incident erosive esophagitis, as a secondary objective of a trial which tested the efficacy of treatment of H. pylori on the symptoms of functional dyspepsia. SUBJECTS/METHODS: Upper gastrointestinal endoscopy and anthropometric assessments were performed, at baseline and after 12 months, in H. pylori positive patients with functional dyspepsia who had no baseline reflux symptoms or esophagitis. Patients were randomly assigned to receive omeprazole, amoxicillin, and clarithromycin (antibiotic group; n = 201) or omeprazole plus placebo (control group; n = 203). The primary outcome was the incidence of esophagitis 12 months after randomization, according to treatment groups, and the association of BMI and other anthropometric measurements. RESULTS: Four hundred and four patients were included (mean age, 46.1 years; 78.7% women). The 12-month follow-up endoscopic esophagitis rates for the antibiotic and control groups were 10.9% (22/201) and 9.4% (19/203), respectively (p = 0.60). The number needed to harm was 67. Baseline anthropometric measurements were performed in 94% (380/404) of patients. The 12-month follow-up esophagitis rates for overweight and normal body weight patients were 13.6% (29/213) and 6.0% (10/167), respectively (p = 0.015); rates for patients with and without increased baseline waist circumference were 15.4% (24/156) and 6.7% (15/224), respectively (p = 0.006). Following logistic regression, only the combination of increased baseline body mass index and waist, but not H. pylori treatment, was independently associated with new-onset esophagitis (OR 2.88; 95% CI: 1.28-6.45). CONCLUSIONS: Excess body weight and concomitant increased waist circumference, but not H. pylori treatment, predicts new-onset esophagitis.

Hepatitis C virus (HCV) viremia in HIV-infected patients without HCV antibodies detectable by third-generation enzyme immunoassay.

BACKGROUND: The detection of hepatitis C virus antibody (anti-HCV) by enzyme immunoassay to screen HCV infection in HIV-1-infected individuals may yield false negative results, especially in patients with advanced immunosuppression. In such cases, a diagnosis would be possible only by use of a viral RNA detection technique. Third-generation anti-HCV enzyme immunoassays seem to have superior performance compared to second-generation immunoassays in this context. METHODS: A cross-sectional study was conducted to ascertain the presence of HCV by polymerase chain reaction (PCR) in 61 HIV-1-infected patients with CD(4)(+) cell counts <200 cells/mm(3), and no detectable HCV antibodies by a third-generation enzyme immunoassay. RESULTS: Six (10%) of 61 patients tested HCV-RNA positive by PCR assay. There was one patient who seroconverted during observation. Hence, there were five patients with HCV viremia without detectable antibodies to HCV throughout the study, which represents 8.2% (95% confidence interval: 2.8-18.4) of 61 HIV-1-infected patients. All five carriers of HCV viremia had CD4 counts <100 cells/mm(3) and were diagnosed with an opportunistic disease at some stage. CONCLUSIONS: The HCV viremia and no detectable HCV antibodies by third-generation immunoassay were found only in individuals with a CD(4) count of <100 cells/mm(3). Molecular assays to detect HCV-RNA should be considered as an important tool to diagnose hepatitis C in HIV-1-infected patients with advanced immunosuppression.

Plasma endothelin-1 levels after coronary stenting in humans.

Endothelin (ET)-1 levels were analyzed in patients who underwent elective coronary stenting. There was a significant increase in systemic ET-1 levels immediately after the procedure, which is probably a marker of endothelial dysfunction that is associated with arterial injury. However, there was no association between ET-1 levels and in-stent restenosis in humans.

Violência sexual e sua prevalência em adolescentes de Porto Alegre, Brasil / Sexual violence and its prevalence among adolescents, Brazil

OBJETIVO: Verificar a prevalência da exposiçäo à violência sexual entre adolescentes estudantes de escolas estaduais. MÉTODOS: Foram selecionadas 52 escolas estaduais de Porto Alegre, RS, Brasil, com ensino fundamental completo, por meio de um processo de amostragem aleatória, estratificada de acordo com o tamanho das escolas. Foi selecionada, em cada escola, uma turma de oitava série por sorteio aleatório e foram incluídos todos os adolescentes presentes nas salas de aula que consentiram em participar do estudo. Foi utilizado o instrumento Triagem da Exposiçäo de Crianças à Violência na Comunidade para identificar jovens que foram vítimas, testemunhas ou que conheciam vítimas de atos de violência sexual. RESULTADOS: Foram incluídos 1.193 adolescentes, representando 10,3 por cento dos alunos matriculados na oitava série da rede estadual da cidade. Vinte e sete (2,3 por cento) adolescentes relataram ter sido vítimas de violência sexual, 54 (4,5 por cento) ter sido testemunhas de algum tipo de violência sexual e 332 (27,9 por cento) relataram conhecer alguém que tenha sido vítima de violência sexual. CONCLUSOES: A exposiçäo à violência sexual pelas três formas de contato relatadas mostrou-se freqüente entre os adolescentes estudados. Säo necessários estudos que abordem a violência sexual como um fenômeno social amplo, com múltiplos fatores associados, amparando estratégias comunitárias de prevençäo e de tratamento

[Sexual violence and its prevalence among adolescents, Brazil]. / Violência sexual e sua prevalência em adolescentes de Porto Alegre, Brasil.

OBJECTIVE: To assess the prevalence o sexual violence among adolescents of public schools. METHODS: Fifty-two public elementary schools of Porto Alegre, Brazil, were selected through random sampling stratified by school size. An 8th grade class was selected in each school through simple random sampling and all adolescents attending the classes who agreed to participate were included in the study. The Screening Survey of Children's Exposure to Community Violence was used to identify adolescents who were victims, witnesses or knew someone who had been a victim of sexual violence. RESULTS: There were 1,193 adolescents included in the study, representing 10.3% of all students enrolled on 8th grade classes in the city's public schools. Twenty-seven adolescents (2.3%) reported being victims of sexual violence, 54 (4.5%) reported witnessing some episode of sexual violence and 332 (27.9%) reported knowing someone who was a victim of sexual violence. CONCLUSIONS: Exposure to sexual violence in any of the three forms of contact was a common event among the studied adolescents. Studies focusing sexual violence as a broad social phenomenon with multiples associated factors are necessary to support preventive and treatment strategies at the community level.