Development and validation of near-infrared brain blood-oxygen monitor / 生物医学工程学杂志

The main purpose of this paper is to describe the design and development of the near-infrared blood-oxygen monitor which is based on the theory of detecting the blood-oxygen parameters of tissue by near-infrared, and the monitor can detect the blood-oxygen parameters of two sides of the local brain tissue. The monitor uses two wavelength ultra-high light LED as lamp-house, and two sensors detect the light scattered by two sides of the local brain tissue, which make the monitor achieve the function of dual detector. The appearance of the monitor's detector is designed to reduce effectively the noise brought by the background and alleviate the discomfort feelings of the patient. At the same time, this apparatus can monitor continuously the brain blood-oxygen parameters of the patients in real time, and output the curves of the blood-oxygen and oxygen concentration of two sides of brain tissue. At last, the biological model experiments and the tests in clinical setting validate the monitor.

Experimental research on non-invasive near-infrared detection of early hepatocirrhosis / 生物医学工程学杂志

This experiment was carried out to make an exaluation on the non-invasive near-infrared detection of early hepatocirrhosis. The model of early hepatocirrhosis was established by injecting carbon tetrachloride in mice. Blood and oxygen content in liver tissue were detected with Runman System. The undulated forms of blood and oxygen variation were extracted and analyzed under the software MATLAB. Non-invasive near-infrared detection was found to react sensitively to the variation of the blood and oxygen content in the early hepatocirrhosis. The rhythm of the undulated forms of blood and oxygen in the early hepatocirrhosis was irregular. The main frequency peak of auto-power spectrum was found to move back to the rang 1.0-1.5 Hz and multi-peak was seen. These show that the non-invasive near-infrared detection is of some value in detecting early hepatocirrhosis.