RESUMO
BACKGROUND: Vascular phenotype by assessing carotid-femoral pulse wave velocity (cf-PWV) and central SBP (cSP) in the young could be used as an intermediate cardiovascular outcome measure. Tonometry is considered the gold-standard technique, but its use is challenging in clinical practice, especially when used in children. The purpose of this study was to validate cf-PWV and cSP assessment with novel oscillometric device (SphygmoCor XCEL) in children and adolescents. METHODS: cf-PWV and cSP were measured in 72 children and adolescents aged 6-20 years. Measurements were performed by applanation tonometry and by the SphygmoCor XCEL device at the same visit under standardized conditions. Regression analysis and Bland-Altman plots were used for comparison of the tonometer-based with oscillometric-based method. RESULTS: Mean cf-PWV measured by applanation tonometry was 4.85â±â0.81âm/s and measured by SpygmoCor XCEL was 4.75â±â0.81âm/s. The mean difference between the two devices was 0.09â±â0.47âm/s (Pâ=âNS). cSP measured by SpygmoCor XCEL was strongly correlated with cSP measured by applanation tonometry (Râ=â0.87, Pâ<â0.001). Mean cSP measured by applanation tonometry was 103.23â±â9.43âmmHg and measured by SpygmoCor XCEL was 103.54â±â8.87âmmHg. The mean cSP difference between the two devices was -0.30â±â3.34âmmHg (Pâ=âNS), and fulfilled the AAMI criterion 1. The estimated intersubject variability was 2.17âmmHg. CONCLUSION: The new oscillometric SphygmoCor XCEL device provides equivalent results for cf-PWV and cSP values to those obtained by tonometry in children and adolescents. Thus, the SphygmoCor XCEL device could be appropriate for assessing cf-PWV and cSP in the pediatric population.