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BACKGROUND: The study aimed to evaluate the association of genetic variants in MIR3142HG with the predisposition of IgA nephropathy (IgAN) in a Chinese Han population. METHODS: Six single-nucleotide polymorphisms (SNPs) in MIR3142HG were chosen for genotyping among 417 IgAN cases and 424 healthy controls using Agena MassARRAY technique. Logistic regression models adjusted for age and gender were used to calculate odds ratios (ORs) and 95% confidence intervals (CI). Haploview and multifactor dimensionality reduction analysis were used to analyze the role of combined SNPs in IgAN risk. RESULTS: Rs17057846-AA genotype (OR = 2.11, 95% CI: 1.04-4.27, p = 0.039) and rs58747524-CC genotype (OR = 1.89, 95% CI: 1.06-3.38, p = 0.032) had the higher risk for IgAN developing in the overall. Interestingly, rs7727115 had a reduced risk for IgAN in females, while rs17057846, rs2961920, and rs58747524 were related to the increased susceptibility to IgAN in females and the subjects with age ≤35 years; moreover, rs17057846 and rs58747524 conferred to the higher risk for Lee's grade ≥III IgAN (p < 0.05 for all). Besides, the combination of rs1582417, rs7727115, and rs2961920 was the best model (testing accuracy = 0.5468, CVC = 10/10, p < 0.001) to predict IgAN predisposition compared to the single SNP alone. CONCLUSIONS: Our study firstly indicated that rs17057846 and rs58747524 in MIR3142HG contributed to the elevated risk for IgAN in a Chinese Han population. These results might provide a new insight for the molecular mechanism in the progression of IgAN.
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Objective: In this study, we investigated the feasibility and efficacy of immediate breast augmentation with autologous fat grafting after removal of polyacrylamide hydrogel (PAAG) and fibrotic capsule. Methods: A retrospective study was conducted on 162 female patients who underwent removal of breast filler PAAG and the fibrotic capsule which produced after injection of PAAG via areola omega-shaped incision. Then autologous fat grafting was immediately performed evenly and radially around the areola via the same incision into different layers (subcutaneous, submammary tissue, pectoralis major intramuscular, and inferior pectoralis major space) except the empty cavity. The cavity left by removal of PAAG and fibrous capsule was closed with negative pressure drainage tube and slight external pressure. Results: All patients recovered well without severe complications. The average score of postoperative satisfaction with physical well-being: chest was 99.83 (total score: 100) compared with the average satisfaction score of 71.69 (total score: 100) preoperatively by means of BREAST-Q™ evaluation (p < 0.01). All patients were satisfied with their postoperative breast shape. Conclusions: Removing as much as possible is critical for patients who underwent the PAAG injection. Our experience in immediate breast augmentation with autologous fat grafting after removal of PAAG and fibrotic capsule proved useful and effective to maintain the balance between removing the PAAG as much as possible and retaining soft tissue to reshape breasts. Level of Evidence: IV.
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BACKGROUND: With the development of breast augmentation and the increased people's pursuit of beauty, more and more women choose breast prosthesis breast augmentation. This study aimed to evaluate the incidence of capsular contracture after breast augmentation with textured and smooth breast prostheses by meta-analysis. METHODS: Studies relating to capsular contracture after breast augmentation with textured breast prosthesis and smooth breast prosthesis were retrieved from the Chinese Journal Full-text Database (CNKI), VIP, the Wanfang Science and Technology Journal Full-text Database, the Chinese Biomedical Literature Search Database (CBM), PubMed, Embase, and the Cochrane Library. The search period was from database establishment to October 2021. EndNote X9 software (Clarivate, Philadelphia, PA, USA) was used to screen and exclude duplicate studies, screen the studies according to the inclusion and exclusion criteria, and extract data for quality evaluation. The data were recorded using the Stata 15.1 software (StataCorp LLC, College Station, TX, USA), and a meta-analysis was performed on the incidence of capsular contracture after breast augmentation with textured and smooth breast prostheses. Finally, the reliability of the results was assessed by sensitivity analysis. A funnel plot was used to evaluate the publication bias of the literature. RESULTS: A total of 13 articles were included, and the total sample size of the study was 5,440. The results of the meta-analysis showed that the incidence of capsular contracture after breast augmentation with textured breast prostheses was significantly lower than that with smooth breast prostheses (OR =0.26; 95% CI: 0.08, 0.81; P<0.05). DISCUSSION: The incidence of capsular contracture after breast augmentation with textured breast prosthesis is significantly lower than that with smooth breast prosthesis.
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BACKGROUND: External volume expander (EVE)-assisted autologous fat grafting is suitable for breast augmentation, but no large sample study in Asia has confirmed this method. OBJECTIVES: The authors reported their experience and outcomes in augmentation mammoplasty with EVE-assisted autologous fat grafting. METHODS: A retrospective study was conducted in 305 female patients who underwent augmentation mammoplasty with EVE-assisted fat grafting between September 2012 and December 2020. Doctors utilized Crisalix (Crisalix S.A., Lausanne, Switzerland) for 3-dimensional (3D) imaging acquisition to measure the increase in breast volume to evaluate doctor satisfaction. The Preoperative Satisfaction with Breast and BREAST-Q questionnaires were employed to assess patients' preoperative and postoperative satisfaction, respectively. RESULTS: The 305 female patients were aged 18 to 50 years (mean, 35.9 years). Among them, 68.52% were "very satisfied," 18.69% were "somewhat satisfied," 11.15% were "somewhat dissatisfied," and 1.64% were "very dissatisfied" based on BREAST-Q analysis, whereas 100% were dissatisfied according to the Preoperative Satisfaction with Breast questionnaire. Doctors employed Crisalix to measure the increase in breast volume to evaluate doctor satisfaction. The results showed 76.01% had an increase in breast volume of 150 to 250 mL or >250 mL and were "satisfied" and "very satisfied," respectively, 21.64% had an increase of 50 to 149 mL and were "somewhat satisfied," and 2.30% had an increase <50 mL and were "dissatisfied." There were no complications, such as obvious fat liquefaction, infection, or fat embolism. CONCLUSIONS: Augmentation mammoplasty with EVE-assisted fat grafting is effective and satisfying in China. Crisalix for 3D imaging acquisition is convenient and effective in measuring breast volume.
