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1.
Nutrients ; 16(11)2024 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-38892716

RESUMO

Maternal breast milk plays a key role in providing newborns with passive immunity and stimulating the maturation of an infant's immune system, protecting them from many diseases. It is known that diet can influence the immune system of lactating mothers and the composition of their breast milk. The aim of this study was to establish if a supplementation during the gestation and lactation of Lewis rats with extra virgin olive oil (EVOO), due to the high proportion of antioxidant components in its composition, has an impact on the mother's immune system and on the breast milk's immune composition. For this, 10 mL/kg of either EVOO, refined oil (control oil) or water (REF group) were orally administered once a day to rats during gestation and lactation periods. Immunoglobulin (Ig) concentrations and gene expressions of immune molecules were quantified in several compartments of the mothers. The EVOO group showed higher IgA levels in both the breast milk and the mammary glands than the REF group. In addition, the gene expression of IgA in mammary glands was also boosted by EVOO consumption. Overall, EVOO supplementation during gestation and lactation is safe and does not negatively affect the mother's immune system while improving breast milk immune composition by increasing the presence of IgA, which could be critical for an offspring's immune health.


Assuntos
Lactação , Azeite de Oliva , Ratos Endogâmicos Lew , Animais , Feminino , Gravidez , Ratos , Fenômenos Fisiológicos da Nutrição Materna , Imunoglobulina A/metabolismo , Imunoglobulina A/análise , Sistema Imunitário/efeitos dos fármacos , Suplementos Nutricionais , Glândulas Mamárias Animais/imunologia , Glândulas Mamárias Animais/metabolismo , Leite/química , Leite/imunologia , Leite Humano/química , Leite Humano/imunologia
2.
Food Chem ; 391: 133211, 2022 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-35598388

RESUMO

Maternal breast milk provides the newborn with passive immunity and stimulates the maturation of the infant immune system. The aim of the present study was to evaluate the vertical transmission of phenolic compounds and their metabolites to offspring in rats fed with extra virgin olive oil (EVOO) during pregnancy and lactation. For this purpose, plasma and lactic serum from dams and plasma from offspring were analyzed by LC-ESI-LTQ-Orbitrap-MS. Both enzymatic and microbial metabolites of hydroxytyrosol and tyrosol were detected in dam plasma and lactic serum. In addition, significant levels of phenolic compounds and their metabolites were found in offspring plasma. The concentration and number of hydroxytyrosol derivatives was higher than those of tyrosol and the microbial metabolites were found in the highest concentration. The observed vertical transmission of EVOO phenolic compounds, whose health benefits are widely reported, provides further support for the importance of the maternal diet during pregnancy and lactation.


Assuntos
Fenóis , Fenômenos Fisiológicos da Nutrição Pré-Natal , Animais , Cromatografia Líquida , Feminino , Humanos , Lactação , Azeite de Oliva , Fenóis/análise , Gravidez , Ratos
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