1.
Org Lett
; 25(31): 5762-5767, 2023 Aug 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37500499
RESUMO
An efficient and chemoselective transformation of ß-amido ynones to 3-acyl-substituted quinolones 2 and 3-H-quinolones 4 has been developed. In this reaction, ß-cyclic amido ynones can be selectively transformed into quinolones 2 in anhydrous EG via a selective CâO bond cleavage, 1,5-O migration, and CâC bond recombination process. The practical approach of this reaction renders it a viable alternative for the construction of various quinolones.