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Hum Pathol ; 141: 183-200, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36775105

RESUMO

Ancillary tests are commonly used in the surgical pathology setting for diagnosing challenging neoplastic diseases of the liver and biliary tract, while histology and clinical correlation remain to be critically important. With continuous discoveries, more and more useful ancillary tests have become available, which can help distinguish between malignant and benign hepatocellular neoplasms, malignant and benign biliary tract entities, and intrahepatic and metastatic carcinomas. This review will focus on existing and emerging biomarkers (such as glutamine synthetase, organic anion transporting polypeptide 1B3, insulin-like growth factor-II mRNA binding protein-3, S100P, SMAD4, enhancer of zeste homolog 2, albumin, hepatocyte nuclear factor-1ß, etc.) that can be used for the diagnosis, classification and prognostication of hepatobiliary neoplasms.


Assuntos
Neoplasias dos Ductos Biliares , Carcinoma Hepatocelular , Colangiocarcinoma , Neoplasias Gastrointestinais , Neoplasias Hepáticas , Humanos , Neoplasias dos Ductos Biliares/diagnóstico , Neoplasias dos Ductos Biliares/patologia , Neoplasias Hepáticas/patologia , Colangiocarcinoma/diagnóstico , Colangiocarcinoma/patologia , Carcinoma Hepatocelular/diagnóstico , Carcinoma Hepatocelular/metabolismo
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