RESUMO
INTRODUCTION: This study evaluated the association between serum cystatin C and residual renal function (RRF) in peritoneal dialysis (PD) patients. METHODS: The ability of cystatin C to predict RRF was assessed. Multivariate linear regression analysis was conducted to measure the impact of particular factors on serum cystatin C levels. RESULTS: The study included 141 PD patients. Serum creatinine and cystatin C were negatively correlated with RRF (p < 0.05). Receiver operating characteristic (ROC) curves showed that serum creatinine and cystatin C could both predict RRF status (p < 0.05), but serum cystatin C had a larger area AUC than creatinine (0.893 vs. 0.757, respectively), p < 0.001). Multiple linear regression analysis revealed that RRF Kt/V and Ccr were independent factors affecting serum cystatin C levels (p < 0.001). CONCLUSION: Serum cystatin C levels were closely associated with RRF in PD patients and could reliably predict RRF status. Serum cystatin C levels were determined by RRF, not by PD.
Assuntos
Falência Renal Crônica , Diálise Peritoneal , Humanos , Creatinina , Cistatina C , Rim/fisiologia , Curva ROCAssuntos
Cadeias Leves de Imunoglobulina/sangue , Nefropatias/sangue , Paraproteinemias/sangue , Diagnóstico Diferencial , Feminino , Humanos , Cadeias kappa de Imunoglobulina/sangue , Cadeias lambda de Imunoglobulina/sangue , Nefropatias/tratamento farmacológico , Testes de Função Renal , Pessoa de Meia-Idade , Paraproteinemias/tratamento farmacológicoAssuntos
Infecções Relacionadas a Cateter/diagnóstico , Cateteres de Demora/efeitos adversos , Falha de Equipamento , Diálise Peritoneal Ambulatorial Contínua/efeitos adversos , Adulto , Infecções Relacionadas a Cateter/terapia , Remoção de Dispositivo/métodos , Humanos , Falência Renal Crônica/diagnóstico , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Diálise Peritoneal Ambulatorial Contínua/métodos , Peritonite/diagnóstico , Peritonite/terapia , Resultado do TratamentoRESUMO
We investigated whether serum cystatin C predicted treatment failure and mortality in nondiabetic peritoneal dialysis (PD) patients. We studied 163 new-onset, nondiabetic PD patients between January 2010 and January 2019. Patients were followed up until death or 1 July 2019. Serum cystatin C was measured within 1 week before PD. Basic demographic and laboratory test data were collected. Patients were divided into low (<5.54 mg/L) and high (≥5.54 mg/L) serum cystatin C groups. The Kaplan-Meier method and log-rank test showed that the technical survival rate of the low cystatin C group was higher than that of the high cystatin C group. There was no difference in overall survival between the two groups. Multivariate Cox model showed that serum cystatin C was an independent risk factor for PD failure. Serum cystatin C could predict PD failure but was not associated with mortality in nondiabetic PD patients.
