High HER-2 protein levels correlate with clinicopathological features in colorectal cancer.

AIM: To obtain a correlation between HER-2 expression and the clinicopathological features incolorectal cancers. (CRCs) using a meta.analysis based approach. MATERIALS AND METHODS: Electronic databases and reference lists were searched for relevant published studies. After inclusion and exclusion criteria were applied, case and control studies related to research topic were included in present meta-analysis. Data analysis was performed using Comprehensive Meta Analysis. (CMA) 2.0 software. RESULT: A total of 30 studies comprising 4,942 CRC patients and 521 healthy controls met the inclusion criteria. Our major results implied that the expression level of HER-2 was significantly higher in CRC patients than healthy controls (odds ratio (OR) = 10.436, 95% confidence interval (CI) = 5.498-19.810, P < 0.001). Sample stratification based on Dukes stages suggested that increased expression level of HER-2 protein was found in CRC patients with Dukes C/D compared with CRC patients with Dukes A/B (OR = 0.335, 95% CI = 0.198-0.568, P < 0.001). The current meta-analysis also found that, in CRC patients with lymph node metastasis (LNM), the HER-2 expression was significantly higher than that in CRC patients without LNM (OR = 1.987, 95%CI = 1.209-3.265, P = 0.007). CONCLUSION: Our meta-analysis study strongly suggests that HER-2 expression levels are clearly correlated with the clinicopathological features in CRC; therefore, HER-2 may be a potential biomarker for diagnosis and prognosis of CRC.

Visible lasers were better than invisible lasers in accelerating burn healing on diabetic rats.

OBJECTIVE: This study was designed to assess and compare the efficacy of accelerating burn healing in diabetic rats using low-power visible and invisible lasers. BACKGROUND DATA: Low-level laser therapy (LLLT) has been used in a number of diabetic animal and human studies, with both positive and no effects. MATERIALS AND METHODS: Male Sprague-Dawley rats were used in the study. Streptozotocin (70 mg/kg) was given for diabetes induction. A burn wound was created on the shaved back of the animals using a metal rod heated to 600 degrees C. The study was performed using 532-, 633-, 670-, 810-, and 980-nm diode lasers. Incident doses of 5, 10, 20, and 30 J/cm(2) and a treatment schedule of three times per week were used in the experiments. The burned areas on all rats were measured and plotted on a chart, and the slope values (mm(2)/d) and the percentages of burn healing were compared. RESULTS: The percentage of burn healing on diabetic rats after LLLT was 78.37% for the visible lasers and 50.68% for the invisible lasers. There was a significant difference (p < 0.005) between visible lasers and invisible lasers in the percentage of burn healing on diabetic rats after laser therapy. CONCLUSION: LLLT at the appropriate treatment parameters can accelerate burn healing on diabetic rats using both visible and invisible lasers. The effects of visible lasers were better than those of invisible lasers in accelerating burn healing on diabetic rats in this study.

Low-level laser therapy enhances wound healing in diabetic rats: a comparison of different lasers.

OBJECTIVE: The effects of wound healing acceleration on diabetic rats were determined and compared using different laser wavelengths and incident doses. BACKGROUND DATA: Many studies have demonstrated that low-level laser therapy (LLLT) can promote the wound healing on non-diabetic animals. METHODS: Male Sprague-Dawley rats were used. Streptozotocin (70 mg/kg) was applied for diabetes induction. An oval full-thickness skin wound was created aseptically with a scalpel in 51 diabetic rats and six non-diabetic rats on the shaved back of the animals. The study was performed using 532, 633, 810, and 980 nm diode lasers. Incident doses of 5, 10, 20, and 30 J/cm(2) and treatment schedule of 3 times/week were used in the experiments. The area of wound on all rats was measured and plotted on a slope chart. The slope values (mm(2)/day), the percentage of relative wound healing, and the percentage of wound healing acceleration were computed in the study. RESULTS: Mean slope values were 6.0871 in non-diabetic control and 3.636 in diabetic control rats (p > 0.005). The percentages of wound healing acceleration were 15.23, 18.06, 19.54, and 20.39 with 532-nm laser, 33.53, 38.44, 32.05, and 16.45 with 633-nm laser, 15.72, 14.94, 9.62, and 7.76 with 810-nm laser, and 12.80, 16.32, 13.79, and 7.74 with 980-nm laser, using incident doses of 5, 10, 20, and 30 J/cm(2), respectively. There were significant differences (p > 0.001) in the mean slope value of wound healing on diabetic rats between control groups and treatment groups in 532, 633, 810, and 980 nm lasers. CONCLUSION: The wound healing on control rats with diabetes was slower than on control rats without diabetes. LLLT at appropriate treatment parameters can enhance the wound healing on diabetic rats. The optimum wavelength was 633 nm, and the optimum incident dose was 10 J/cm(2) in our study.

[Reversed C-ring flap from the middle and ring fingers for repairing distal degloving injury of the thumb and forefinger].

C-ring flap is currently an advanced means for repair of degloving injuries of the fingers. From May, 1999 to September, 2002, we used reversed C-ring flap middle and ring finger for repairing distal degloving injury to the thumb and forefinger in 9 cases. All flaps survived with satisfactory appearance. This operation can be easily and conveniently performed that allow early resection of the pedicle, but its application is relatively limited and the transferred flap usually hasa poor sensory function, with also obvious damage to the appearance of the donor finger.