High-entropy oxides: an emerging anode material for lithium-ion batteries.

High entropy oxides (HEOs) have gained significant attention in multiple research fields, particularly in reversible energy storage. HEOs with rock-salt and spinel structures have shown excellent reversible capacity and longer cycle spans compared to traditional conversion-type anodes. However, research on HEOs and their electrochemical performance remains at an early stage. In this highlight, we review recent progress on HEO materials in the field of lithium-ion batteries (LIBs). Firstly, we introduce the synthesis methods of HEOs and some factors that affect the morphology and electrochemical properties of the synthesized materials. We then elaborate on the structural evolution of HEOs with rock-salt and spinel structures in lithium energy storage and summarize the relationship between morphology, pseudocapacitance effect, oxygen vacancy, and electrochemical performance. In the end, we give the challenges of HEO anodes for LIBs and present our opinions on how to guide the further development of HEOs for advanced anodes.

Lnc SMAD5-AS1 as ceRNA inhibit proliferation of diffuse large B cell lymphoma via Wnt/ß-catenin pathway by sponging miR-135b-5p to elevate expression of APC.

Diffuse large B cell lymphoma (DLBCL) is a common and fatal hematological malignancy. Long noncoding RNAs (lncRNAs) have emerged as crucial biomarkers and regulators in many cancers. Novel lncRNA biomarker in DLBCL needs to be investigated badly, as well as its function and molecular mechanism. To further explore, microarray analysis was performed to identify the differentially expressed lncRNAs in DLBCL tissues. To investigate the biological functions of SMAD5-AS1, we performed gain- and loss-of-function experiments in vitro and in vivo. Furthermore, bioinformatics analysis, dual-luciferase reporter assays, Argonaute 2-RNA immunoprecipitation (AGO2-RIP), RNA pull-down assay, quantitative PCR arrays, western blot assay, TOPFlash/FOPFlash reporter assay, and rescue experiments were conducted to explore the underlying mechanisms of competitive endogenous RNAs (ceRNAs). We found that SMAD5-AS1 was down-regulated in DLBCL tissues and cell lines. Functionally, SMAD5-AS1 downregulation promoted cell proliferation in vitro and in vivo, whereas SMAD5-AS1 overexpression could lead to the opposite effects in vitro and in vivo. Bioinformatics analysis and luciferase assays revealed that miR-135b-5p was a direct target of SMAD5-AS1, which was validated by dual-luciferase reporter assays, AGO2-RIP, RNA pull-down assay, and rescue experiments. Also, dual-luciferase reporter assays and rescue experiments demonstrated that miR-135b-5p targeted the adenomatous polyposis coli (APC) gene directly. SMAD5-AS1/miR-135b-5p inhibits the cell proliferation via inactivating the classic Wnt/ß-catenin pathway in the form of APC dependency. Our results indicated that SMAD5-AS1 inhibits DLBCL proliferation by sponging miR-135b-5p to up-regulate APC expression and inactivate classic Wnt/ß-catenin pathway, suggesting that SMAD5-AS1 may act as a potential biomarker and therapeutic target for DLBCL.