High Sensitivity Triboelectric Based Flexible Self-Powered Tactile Sensor with Bionic Fingerprint Ring Structure.

Flexible self-powered tactile sensors, with applications spanning wearable electronics, human-machine interaction, prosthetics, and soft robotics, offer real-time feedback on tactile interactions in diverse environments. Despite advances in their structural development, challenges persist in sensitivity and robustness, particularly when additional functionalities, such as high transparency and stretchability. In this study, we present a novel approach integrating a bionic fingerprint ring structure with a PVDF-HFP/AgNWs composite fiber electrode membrane, fabricated via 3D printing technology and electrospinning, respectively, yielding a triboelectric nanogenerator (TENG)-based self-powered tactile sensor. The sensor demonstrates high sensitivity (5.84 V/kPa in the 0-10 kPa range) and rapid response time (10 ms), attributed to the microring texture on its surface, and exhibits exceptional robustness, maintaining electrical output integrity even after 24,000 cycles of loading. These findings highlight the potential of the microring structures in addressing critical challenges in flexible sensor technology.

Long-Distance Continuous Self-Transport of a Droplet by Merging Droplets on a Graphene-Covered Multibranch Gradient Groove Surface.

Although the self-transport of liquid droplets by a gradient-textured substrate can break away from the energy input, the long distance and even continuous spontaneous motion of droplets will be limited by the length in the surface-gradient direction. This article introduces a novel design with a monolayer graphene-covered multibranch gradient groove surface (GMGGS). The design aims to achieve long-distance, continuous self-transport of a mercury (Hg) droplet by merging with other mercury droplets, and the process is carried out using molecular dynamics (MD) simulation. This method achieves the merging of mercury droplets through the structure of multibranch gradient grooves, and we have observed that the merged mercury droplet can be reaccelerated in the gradient groove. The results demonstrate that droplet merging allows for control over the surface morphology variations of mercury droplets within the gradient groove. This creates a forward pressure difference, which leads to reacceleration of the mercury droplets. In light of this mechanism, the trunk droplet can achieve long-distance continuous self-transport on the GMGGS by continuously merging with branch droplets. These findings will broaden our comprehension of droplet merging and self-transport behavior, offering corresponding theoretical support for the long-distance continuous self-transport of droplets.

Ultrahigh Efficient Collection of Underwater Bubbles by High Adsorption and Transport, Coalescence, and Collection Integrating a Conical Arrayed Surface.

The capture and utilization of underwater fuel bubbles such as methane can alleviate the greenhouse effect, solve the global energy crisis, and possibly improve the endurance of underwater equipment. However, previous research routinely failed to achieve the integrated process of continuous adsorption, transportation, and collection of bubbles limited by the trade-off between the bubble adhesion and transport efficiency dependent on interfacial pinning, tremendously hindering the direct capture and utilization of underwater fuel bubbles. To break through this bottleneck, a magnetic-guided conical arrayed surface (CAS) associated with a laser etching technique is fabricated conveniently to realize superhydrophobicity. The bubbles on laser-etched CAS have higher adhesiveness and low-pinning transport compared with those on the nonlaser-etched surface. Intriguingly, the gas film adsorbed within the CAS seems to be a gas channel, which accelerates the bubble coalescence and fast spreading to eventually realize the integration of transport, coalescence, and collection. The dynamic behaviors of bubble adsorption, transportation, and coalescence on CAS are probed to reveal the mechanism of the gas film-generating process within conical arrays. Furthermore, a novel underwater bubble-collecting device with multiangled CAS is proposed to achieve multidirectional capture, highly efficient transportation, and collection of rising bubbles. The results advance our understanding of dynamic behaviors of bubbles at solid-liquid interfaces and facilitate design and manufacturing of an apparatus for bubble collection.

Temperature-responsive peristome-structured smart surface for the unidirectional controllable motion of large droplets.

The manipulation of fast, unidirectional motion for large droplets shows important applications in the fields of fog collection and biochemical reactions. However, driving large droplets (>5 µL) to move directionally and quickly remains challenging due to the nonnegligible volume force. Herein, we fabricated a scalable, bionic peristome substrate with a microcavity width of 180 µm using a 3D printing method, which could unidirectionally drive a large water droplet (~8 µL) at a speed reaching 12.5 mm/s by temperature-responsive wettability. The substrate surface was grafted with PNIPAAm, which could reversibly change its wettability in response to temperature, thereby enabling a temperature-responsive smart surface that could regulate droplet movement in real-time by changing the temperature. A series of temperature-responsive smart patterns were designed to induce water transport along specific paths to further realize controllable droplet motion with the antibacterial treatment of predesignated areas. The ability to achieve temperature-responsive unidirectional motion and dynamic control of droplet movement could allow programmable fluidic biosensors and precision medical devices. A temperature-responsive smart surface was produced to control the unidirectional motion of large droplets between spreading and pinning movement by changing the surface wettability.

Research progress of bionic fog collection surfaces based on special structures from natural organisms.

With the increasing shortage of water resources, people are seeking more innovative ways to collect fog to meet the growing need for production and the demand for livelihood. It has been proven that fog collection is efficient for collecting water in dry but foggy areas. As a hot research topic in recent years, bionic surfaces with fog collection functions have attracted widespread attention in practical applications and basic research. By studying natural organisms and bionic surfaces, more avenues are provided for the development of fog collection devices. Firstly, starting from biological prototypes, this article explored the structural characteristics and fog collection mechanisms of natural organisms such as spider silk, desert beetles, cactus, Nepenthes and other animals and plants (Sarracenia, shorebird and wheat awn), revealing the fog collection mechanism of the natural organisms based on microstructures. Secondly, based on the theory of interfacial tension, we would delve into the fog collection function's theoretical basis and wetting model, expounding the fog collection mechanism from a theoretical perspective. Thirdly, a detailed introduction was given to prepare bionic surfaces and recently explore fog collection devices. For bionic surfaces of a single biological prototype, the fog collection efficiency is about 2000-4000 mg cm-2 h-1. For bionic surfaces of multiple biological prototypes, the fog collection efficiency reaches 7000 mg cm-2 h-1. Finally, a critical analysis was conducted on the current challenges and future developments, aiming to promote the next generation of fog collection devices from a scientific perspective from research to practical applications.

Synergistic Antibacterial Surface with Liquid Repellency and Enhanced Photothermal Bactericidal Activity.

The presence of microorganisms on biomedical devices and food packaging surfaces poses an important threat to human health. Superhydrophobic surfaces, a powerful tool to combat pathogenic bacterial adhesion, are threatened by their poor robustness. As a supplement, photothermal bactericidal surfaces may be expected to kill adhered bacteria. Using copper mesh as a mask, we prepared a superhydrophobic surface with a homogeneous conical array. The surface shows synergistic antibacterial properties, including a superhydrophobic character against bacterial adhesion and photothermal bactericidal activity. As a result of the excellent liquid repellency, the surface could highly repel the adherence of bacteria after immersing in a bacterial suspension for 10 s (95%) and 1 h (57%). Photothermal graphene can easily eliminate most adhered bacteria during the subsequent treatment of near-infrared (NIR) radiation. After a self-cleaning wash, the deactivated bacteria were easily rinsed off the surface. Furthermore, this antibacterial surface exhibited an approximately 99.9% resisted bacterial adhesion rate regardless of planar and various uneven surfaces. The results offer promising advancement of an antibacterial surface combining both adhesion resistance and photothermal bactericidal activity in fighting microbial infections.

Retraction notice to "Tim-4 promotes the growth of colorectal cancer by activating angiogenesis and recruiting tumor-associated macrophages via the PI3K/AKT/mTOR signaling pathway" [Canc. Lett. 436 (2018) 119-128].

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). .

Hemodynamic alterations with large spontaneous splenorenal shunt ligation during adult deceased donor liver transplantation.

Background: A large spontaneous splenorenal shunt (SRS) will greatly impact portal inflow to the graft during liver transplantation (LT). Direct ligation of a large SRS is an uncommon surgical procedure and the hemodynamic consequences of this procedure are unknown. Methods: In this retrospective study, we described our technique for direct ligation of a large SRS and the consequent hemodynamic changes during LT. 3-Dimensional computed tomography and Doppler ultrasonography were used to evaluate SRS and portal vein blood flow volume (PFV). Results: A total of 22 recipients had large SRS including 13 with PFV <85 ml/min/100 g (ligation group) and 9 with PFV ≥85 ml/min/100 g (no ligation group). The diameter of SRS was significantly larger in the ligation group than in the non-ligation group (22.92 ± 4.18 vs. 16.24 ± 3.60 mm; p = 0.0009). In all ligation patients, the SRS was easily identified and isolated, it was located just below the distal pancreas and beside the inferior mesenteric vein. PV flow increased significantly from 68.74 ± 8.77 to 116.80 ± 16.50 ml/min/100 g (p < 0.0001) after ligation; this was followed by a reduction in peak systolic velocity of the hepatic artery from 58.17 ± 14.87 to 46.67 ± 13.28 cm/s (p = 0.0013). Conclusions: Direct ligation of large SRS was an effective and safe surgical procedure to overcome the problem of portal hypoperfusion during LT.

Correction: Enhanced energy harvester performance by a tension annealed carbon nanotube yarn at extreme temperatures.

Correction for 'Enhanced energy harvester performance by a tension annealed carbon nanotube yarn at extreme temperatures' by Xinghao Hu et al., Nanoscale, 2022, 14, 16185-16192, https://doi.org/10.1039/D2NR05303A.

Enhanced energy harvester performance by a tension annealed carbon nanotube yarn at extreme temperatures.

Carbon nanotube (CNT) yarns generate electrical energy when they were stretched in an electrolyte, and they have been exploited for diverse applications such as self-powered sensors and human health monitoring systems. Here we improved the capacitance change and harvester performance of a coiled CNT yarn by using an incandescent tension annealing process (ITAP). When undergoing stretching cycles at 1 Hz, a coiled ITAP yarn can produce 2.5 times peak electrical power and 1.6 times output voltage than that of a neat CNT yarn. Electrochemical analysis shows that the capacitance of the ITAP yarn decreased by 20.4% when it was stretched to 30% strain. Microstructure results demonstrate that the large capacitance change may result from the densified electrochemical surface by the ITAP. Moreover, the potential of the zero charge (PZC) of ITAP yarns was shifted to a more negative value than that of the neat CNT yarn, which means that more charges were injected into the ITAP yarn once it was immersed in an electrolyte. Thus, the large capacitance change and initial injected charge are two main reasons for enhancing the harvester performance of the ITAP yarn. In addition, by annealing a twisted CNT yarn before it was coiled, we further increased the output peak power density to 170 W kg-1 at a strain of 55%.

PIAS1 Alleviates Hepatic Ischemia-Reperfusion Injury in Mice through a Mechanism Involving NFATc1 SUMOylation.

Recently, attentions have come to the alleviatory effect of protein inhibitor of activated STAT1 (PIAS1) in hepatic ischemia-reperfusion injury (HIRI), but the underlying molecular mechanistic actions remain largely unknown, which were illustrated in the present study. Microarray-based analysis predicted a possible regulatory mechanism involving the PIAS1/NFATc1/HDAC1/IRF-1/p38 MAPK signaling axis in HIRI. Then, growth dynamics of hypoxia/reoxygenation- (H/R-) exposed hepatocytes and liver injury of HIRI-like mice were delineated after the alteration of the PIAS1 expression. We validated that PIAS1 downregulation occurred in H/R-exposed hepatocytes and HIRI-like mice, while the expression of NFATc1, HDAC1, and IRF-1 and phosphorylation levels of p38 were increased. PIAS1 inactivated p38 MAPK signaling by inhibiting HDAC1-mediated IRF-1 through NFATc1 SUMOylation, thereby repressing the inflammatory response and apoptosis of hepatocytes in vitro, and alleviated liver injury in vivo. Collectively, the NFATc1/HDAC1/IRF-1/p38 MAPK signaling axis is highlighted as a promising therapeutic target for potentiating hepatoprotective effects of PIAS1 against HIRI.

Approximation rates of DeepONets for learning operators arising from advection-diffusion equations.

We present the analysis of approximation rates of operator learning in Chen and Chen (1995) and Lu et al. (2021), where continuous operators are approximated by a sum of products of branch and trunk networks. In this work, we consider the rates of learning solution operators from both linear and nonlinear advection-diffusion equations with or without reaction. We find that the approximation rates depend on the architecture of branch networks as well as the smoothness of inputs and outputs of solution operators.

Self-Powered Non-Contact Motion Vector Sensor for Multifunctional Human-Machine Interface.

Sensors as the significant units of the Internet of Things play an important role in the field of information interaction. Non-contact sensors have the advantages of flexible manipulation and a longer lifespan but it is constrained in motion detection due to their relative single detection function. Herein, a self-powered non-contact motion vector sensor (NMVS) for the multifunctional human-machine interface is reported. Based on the electrostatic induction effect, the motion vector is measured according to the output electrical signals from the non-contact triboelectric nanogenerator (NC-TENG). By simulation analysis and experimental validation, the output characteristics of NC-TENG dependence on structural and motion parameters are investigated in detail. On this basis, the resolution of NMVS is improved and exhibits for non-contact micro-vibration monitoring, rehabilitation gait detection, contactless smart lock, and the non-contact limit alarm. This work not only proposes an ingenious strategy for non-contact motion vector detection but also demonstrates the promising prospects of a multifunctional human-machine interface in intelligent electronics, health rehabilitation, and industrial inspection.

High-temperature behavior of hyperthermostable Thermotoga maritima xylanase XYN10B after designed and evolved mutations.

A hyperthermostable xylanase XYN10B from Thermotoga maritima (PDB code 1VBR, GenBank accession number KR078269) was subjected to site-directed and error-prone PCR mutagenesis. From the selected five mutants, the two site-directed mutants (F806H and F806V) showed a 3.3-3.5-fold improved enzyme half-life at 100 °C. The mutant XYNA generated by error-prone PCR showed slightly improved stability at 100 °C and a lower Km. In XYNB and XYNC, the additional mutations over XYNA decreased the thermostability and temperature optimum, while elevating the Km. In XYNC, two large side-chains were introduced into the protein's interior. Micro-differential scanning calorimetry (DSC) showed that the melting temperature (Tm) dropped in XYNB and XYNC from 104.9 °C to 93.7 °C and 78.6 °C, respectively. The detrimental mutations showed that extremely thermostable enzymes can tolerate quite radical mutations in the protein's interior and still retain high thermostability. The analysis of mutations (F806H and F806V) in a hydrophobic area lining the substrate-binding region indicated that active site hydrophobicity is important for high activity at extreme temperatures. Although polar His at 806 provided higher stability, the hydrophobic Phe at 806 provided higher activity than His. This study generates an understanding of how extreme thermostability and high activity are formed in GH10 xylanases. KEY POINTS: • Characterization and molecular dynamics simulations of TmXYN10B and its mutants • Explanation of structural stability of GH10 xylanase.

CircRNA circ_SEC24A upregulates DNMT3A expression by sponging miR-26b-5p to aggravate osteoarthritis progression.

BACKGROUND: Osteoarthritis (OA) is a chronic degenerative disease characterized by degeneration and injury of articular cartilage. Circular RNA_SEC24A (circ_SEC24A; circBase ID: hsa_circ_0005105) is upregulated and promotes multiple tumor processes. However, its role in OA progression remained mostly unknown. METHODS: Quantitative real-time PCR (qRT-PCR) was used to detect the RNA expression of circ_SEC24A, miR-26b-5p and DNA methyltransferase 3 alpha (DNMT3A). Cell proliferation was verified by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide (MTT) and 5-ethynyl-2'-deoxyuridine (EdU) assays. Flow cytometry was used to detect apoptosis. Western blot was used to detect protein expression of DNMT3A, proliferating cell nuclear antigen (PCNA), extracellular matrix (ECM) proteins (Collagen II and Aggrecan), and ECM degrading enzymes (matrix metalloproteinase-13 [MMP13] and metallopeptidase with thrombospondin type 1 motif 5 [ADAMTS5]). The target relationship between miR-26b-5p and circ_SEC24A or DNMT3A was predicted by Statbase3.0 or TargetScan and confirmed by dual-luciferase reporter assay, RNA pull-down assay and RNA immunoprecipitation. RESULTS: Circ_SEC24A was upregulated in osteoarthritic cartilage tissues and IL-1ß-induced chondrocytes, accompanying with miR-26b-5p downregulation and DNMT3A upregulation. Circ_SEC24A expression was resistant to RNase R digestion and mainly expressed in the cytoplasm. Interfering circ_SEC24A abolished IL-1ß-induced effects on proliferation inhibition, apoptosis, and ECM degradation in chondrocytes, but overexpressing circ_SEC24A had the opposite effects. Inhibiting miR-26b-5p counteracted but upregulating miR-26a-5p mimicked the functions of circ_SEC24A silencing. Reinforcing DNMT3A reversed miR-26b-5p overexpression's role in IL-1ß-induced chondrocytes. Mechanically, circ_SEC24A and DNMT3A were competitive endogenous RNAs (ceRNAs) for miR-26b-5p. CONCLUSION: Circ_SEC24A was a promoting factor for IL-1ß-induced OA progression via circ_SEC24A/miR-26b-5p/DNMT3A ceRNA axis.

Electrical energy generation by squeezing a graphene-based aerogel in an electrolyte.

Mechanical energy harvesters are widely studied because of their diverse applications, such as harvesting ocean wave energy, self-powered wireless sensors, portable power supplies and so on. To be feasible, an energy harvester needs to provide a high output current and voltage, in addition to being environmentally friendly. Hence, in this study, a new energy harvester is developed via reversible deformation of a three-dimensional graphene aerogel which was immersed in a salt solution. The movement of solvated ions in the diffusion layer during the squeezing of the electrode induced the transmission of electrons out of graphene, resulting in electrical energy. The developed harvester can supply a power density of 11.7 W kg-1 and an energy density of 14.3 J kg-1, in addition to achieving a high energy conversion efficiency of approximately 43.2%. The device can also generate a high open-circuit voltage and short-circuit current when an external compression strain is applied. Moreover, it can be easily scaled up by being connected in series with multiple harvesters. Thus, the proposed energy harvester can not only be widely used for harvesting ocean wave energy, but also for adsorbing pollutants to prevent the pollution of ocean environments.

Inhibition of EZH2 enhances the therapeutic effect of 5-FU via PUMA upregulation in colorectal cancer.

Although the survival rate of patients with cancer have increased due to the use of current chemotherapeutic agents, adverse effects of cancer therapy remain a concern. The reversal of drug resistance, reduction in harmful side effects and accelerated increase in efficiency have often been addressed in the development of combination therapeutics. Tazemetostat (EPZ-6438), a histone methyltransferase EZH2 selective inhibitor, was approved by the FDA for the treatment of advanced epithelioid sarcoma. However, the effect of tazemetostat on colorectal cancer (CRC) and 5-FU sensitivity remains unclear. In this study, the enhancement of tazemetostat on 5-FU sensitivity was examined in CRC cells. Our findings demonstrated that tazemetostat combined with 5-FU exhibits synergistic antitumor function in vitro and in vivo in CRC cells. In addition, tazemetostat promotes PUMA induction through the ROS/ER stress/CHOP axis. PUMA depletion attenuates the antitumor effect of the combination therapy. Therefore, tazemetostat may be a novel treatment to improve the sensitivity of tumors to 5-FU in CRC therapy. In conclusion, the combination of 5-FU and tazemetostat shows high therapeutic possibility with reduced unfavorable effects.

The miR-30a-5p/CLCF1 axis regulates sorafenib resistance and aerobic glycolysis in hepatocellular carcinoma.

HCC (hepatocellular carcinoma) is a major health threat for the Chinese population and has poor prognosis because of strong resistance to chemotherapy in patients. For instance, a considerable challenge for the treatment of HCC is sorafenib resistance. The aberrant glucose metabolism in cancer cells aerobic glycolysis is associated with resistance to chemotherapeutic agents. Drug-resistance cells and tumors were exposed to sorafenib to establish sorafenib-resistance cell lines and tumors. Western blotting and real-time PCR or IHC staining were used to analyze the level of CLCF1 in the sorafenib resistance cell lines or tumors. The aerobic glycolysis was analyzed by ECAR assay. The mechanism mediating the high expression of CLCF1 in sorafenib-resistant cells and its relationships with miR-130-5p was determined by bioinformatic analysis, dual luciferase reporter assays, real-time PCR, and western blotting. The in vivo effect was evaluated by xenografted with nude mice. The relation of CLCF1 and miR-30a-5p was determined in patients' samples. In this study, we report the relationship between sorafenib resistance and increased glycolysis in HCC cells. We also show the vital role of CLCF1 in promoting glycolysis by activating PI3K/AKT signaling and its downstream genes, thus participating in glycolysis in sorafenib-resistant HCC cells. Furthermore, we also show that miR-30a-5p directly targets CLCF1 and that sorafenib-mediated suppression of miR-30a-5p results in the upregulation of CLCF1 in HCC cells resistant to sorafenib. We also found that when a cholesterol modified agomiR-30a-5p was delivered systemically to mice harboring sorafenib-resistant HCC tumors, tumor growth decreased significantly. There is an uncharacterized mechanism of biochemical resistance to hormone therapies orchestrated by the miR-30a-5p/CLCF1 axis to mediate sorafenib resistance and aerobic glycolysis in HCC. Therefore, this study indicates that targeting the miR-30a-5p/CLCF1 axis may hold promise for therapeutic intervention in HCC sorafenib resistance patients.

Surface slip on rotating graphene membrane enables the temporal selectivity that breaks the permeability-selectivity trade-off.

Membrane separation technology is dictated by the permeability-selectivity trade-off rule, because selectivity relies on membrane pore size being smaller than that of hydrated ions. We discovered a previously unknown mechanism that breaks the permeability-selectivity trade-off in using a rotating nanoporous graphene membrane with pores of 2 to 4 nanometers in diameter. The results show that the rotating membrane exhibits almost 100% salt rejection even when the pore size is larger than that of hydrated ions, and the surface slip at the liquid/graphene interface of rotating membrane enables concurrent ultra-selectivity and unprecedented high permeability. A novel concept of "temporal selectivity" is proposed to attribute the unconventional selectivity to the time difference between the ion's penetration time through the pore and the bypass time required for ion's sliding across the pore. The newly discovered temporal selectivity overcomes the limitation imposed by pore size and provokes a novel theory in designing high-performance membranes.