High expression of 14-3-3Æ¡ indicates poor prognosis and progression of lung adenocarcinoma.

Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related death worldwide. 14-3-3Æ¡ is an intracellular phosphoserine-binding protein that has been proposed to be involved in tumorigenesis. However, the biofunctional role of 14-3-3Æ¡ and its clinicopathological/prognostic significance in LUAD have remained elusive. In the present study, western blot and immunohistochemical analyses of cancer tissues/cells and the corresponding normal controls were performed to verify that 14-3-3Æ¡ was upregulated in LUAD. Univariate and multivariate logistic regression analysis indicated that high expression of 14-3-3Æ¡ predicted poor overall survival and progression-free survival of patients with LUAD. Furthermore, in vivo and in vitro experiments demonstrated that overexpression of 14-3-3Æ¡ markedly promoted cell proliferation, colony formation, anchorage-independent growth and tumor growth, whereas 14-3-3Æ¡ depletion produced the opposite effects. Of note, 14-3-3Æ¡ was identified as an independent prognostic factor for patients with LUAD. Collectively, the present results revealed that high expression of 14-3-3Æ¡ may serve as an independent biomarker, contributing to poor prognosis and progression of LUAD.

[Clinical study on the removal of sellar region tumors by pterional approach (report of 119 cases)].

BACKGROUND & OBJECTIVE: Sellar region tumors are common intracranial tumor. This study was designed to investigate the methods of the removal of tumors in sellar region by pterional approach. METHODS: A total of 119 cases with sellar region tumors were performed operation. Before the operation, the relationships between the tumors and their periphery were determined according to CT, MR and the cerebral angiography and then the tumors were removed by pterional approach microsurgery in 4 different spaces. RESULTS: The number of the patients treated with total, subtotal, and partial resection were 72, 36, and 11, respectively; with 85 cases significantly improved, 24 getting better, 8 without changes and 2 dead. Follow-up half a year, 92 cases were survival in the half a year of follow-up, in which 61 cases were able to work with normal life, 15 could do light work, 9 could take care of themselves but 6 patients were disabled, and 1 died of heart disease. CONCLUSION: Pterional approach can be used to remove many kinds of tumors in sellar region and with better exploration, therefore, increase the total removal and cure rate of such tumors.