A new coumarin glucoside from Angelica pubescens.

A new coumarin glucoside named angelol A-3'-ß-D-glucoside and four known compounds (2-5) were isolated from the root of Angelica pubescens. Their chemical structures were elucidated by extensive spectroscopic methods involving HR-ESI-MS, 1D and 2D NMR. The absolute configuration of compound 1 was confirmed by the CD experiment. All compounds were tested for nitric oxide (NO) inhibitory activity in vitro. The results showed that all compounds exhibited weak to moderate inhibition activities of NO production except compound 5.

[Chemical constituents of cyclic peptides from fibrous roots of Pseudostellaria heterophylla].

Four cyclic peptides were isolated from the 75% ethanol extract of the fibrous roots of Pseudostellaria heterophylla by silica gel, Sephadex LH-20 column chromatography, and semi-preparative HPLC. Through mass spectrometry, NMR and other methods, they were identified as pseudostellarin L(1), heterophyllin B(2), pseudostellarin B(3), and pseudostellarin C(4). Among them, compound 1 was a new cyclic peptide, and compounds 2-4 were isolated from the fibrous roots of P. heterophylla for the first time. None of these compounds displayed cytotoxic activities against MCF-7, A549, HCT-116, and SGC-7901 cells.

A new cyclic peptide from the fibrous root of Pseudostellaria heterophylla.

A new cyclic peptide, Pseudostellarin K (1), together with thirteen known compounds, including two cyclic peptides (2 and 3), one ß-carboline alkaloid (4), two amides (5 and 6), three phenylpropanoids (7-9) and other compounds (10-14), were isolated from the fibrous root of Pseudostellaria heterophylla. Their structures were elucidated by extensive spectroscopic analysis. Compounds 1, 4-6, 10 were isolated from the genus pseudostellaria for the first time. All compounds were evaluated for cytotoxic activities against MCF-7, A549, HCT-116 and SGC-7901 cell lines by MTT assay. Unfortunately, all these compounds displayed weak cytotoxic activities.