Efficacy and safety of 0.01% atropine combined with orthokeratology lens in delaying juvenile myopia: An observational study.

It aims to study the efficacy and safety of low-concentration Atropine combined with orthokeratology (OK) lens in delaying juvenile myopia. This is a prospective study, 172 adolescents aged 8 to 12 years who were admitted to the diopter department of Hengshui People Hospital from April 2021 to May 2022 were selected. According to the equivalent spherical diopter measured at the time of initial diagnosis, myopic patients were randomly divided into low myopia group (group A) and moderate myopia group (group B). At the same time, according to the different treatment methods, the patients were divided into the group wearing frame glasses alone (group c), the group wearing frame glasses with low-concentration Atropine (group d), the group wearing corneal shaping glasses alone at night (group e), and the group wearing corneal shaping glasses at night with low-concentration Atropine (group f). The control effect of myopia development and axial elongation in group f was better than that in groups d and e (P < .05). The effect of controlling myopia development and axial elongation in group f is with P > .05. The probability of postoperative adverse reactions in group f was lower and lower than that in the other groups. Low-concentration atropine combined with OK lens could effectively delay the development of juvenile myopia, and had a high safety. Low-concentration of Atropine would not have a significant impact on the basic tear secretion and tear film stability. Nightwear of OK lens also had no significant impact, but it would significantly reduce the tear film rupture time in the first 3 months, and at the same time, the tear film rupture time would be the same after 6 months as before treatment.

Lower heart rate variability is associated with loss of muscle mass and sarcopenia in community-dwelling older Chinese adults.

BACKGROUND/PURPOSE: Autonomic nervous system (ANS) disorders may occur in skeletal muscle disease, but the link between them has not been fully established. Studying the relationship between them may yield insights into the mechanisms and treatment of disease. This study aimed to explore the association between heart rate variability (HRV), sarcopenia, and subscales of sarcopenia (muscle mass, muscle strength, and physical mobility). METHODS: 2514 community-dwelling older Chinese participants were included in this study. The Asian Working Group for Sarcopenia guidelines were used to define sarcopenia. HRV was measured by 90-s electrocardiogram RR interval data. All HRV parameters were transformed using natural logarithms. Multiple regression analysis and multivariate linear regression was performed using potential correlates. RESULTS: The overall prevalence of sarcopenia was 15.1 % (18.5 % in males and 12.6 % in females). In the logistic regression analysis model, there was a significant association between log-transformed standard deviation of RR interval (lnSDNN) (OR = 0.736, p = 0.019), log-transformed coefficient of variation of RR intervals (lnCVRR) (OR = 0.751, p = 0.020), log-transformed low-frequency power (lnLF) (OR = 0.861, p = 0.008), log-transformed high-frequency power (lnHF) (OR = 0.864, p = 0.003) and sarcopenia in the general population after adjusting for age, sex, body mass index (BMI), daily activity levels, hypertension, heart disease and cardiac drugs. In addition, in multivariate linear regression, lnSDNN (ß = 0.146, p = 0.001), lnCVRR (ß = 0.120, p = 0.010), lnLF (ß = 0.066, p = 0.002) and lnHF (ß = 0.065, p < 0.001) remained significantly positively associated with muscle mass, but there were no significant differences in grip strength and walking speed. CONCLUSIONS: Sarcopenia was independently associated with lower heart rate variability in a community-dwelling elderly Chinese population. In addition, muscle mass was positively associated with heart rate variability in the elderly.

Matrine promotes mitochondrial biosynthesis and reduces oxidative stress in experimental optic neuritis.

Optic neuritis (ON), characterized by inflammation of the optic nerve and apoptosis of retinal ganglion cells (RGCs), is one of the leading causes of blindness in patients. Given that RGC, as an energy-intensive cell, is vulnerable to mitochondrial dysfunction, improving mitochondrial function and reducing oxidative stress could protect these cells. Matrine (MAT), an alkaloid derived from Sophora flavescens, has been shown to regulate immunity and protect neurons in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis and ON. However, the protective mechanism of MAT on RGCs is largely unknown. In this study, we show that MAT treatment significantly reduced the degree of inflammatory infiltration and demyelination of the optic nerve and increased the survival rate of RGCs. The expression of Sirtuin 1 (SIRT1), a member of an evolutionarily conserved gene family (sirtuins), was upregulated, as well as its downstream molecules Nrf2 and PGC-1α. The percentage of TOMM20-positive cells was also increased remarkably in RGCs after MAT treatment. Thus, our results indicate that MAT protects RGCs from apoptosis, at least in part, by activating SIRT1 to regulate PGC-1α and Nrf2, which, together, promote mitochondrial biosynthesis and reduce the oxidative stress of RGCs.

Evaluating the Heterogeneity Effect of Fertilizer Use Intensity on Agricultural Eco-Efficiency in China: Evidence from a Panel Quantile Regression Model.

Chemical fertilizer is one of the most important input factors in agricultural production, but the excessive use of fertilizer inevitably leads to the loss of agricultural eco-efficiency (AEE). Therefore, it is necessary to explore the impact of fertilizer use intensity (FUI) on AEE. However, ordinary panel regression, based on the assumption of parameter homogeneity may yield biased estimation conclusions. In this regard, a panel quantile regression model (QRM) was constructed with the provincial panel data of China from 1978-2020 to test the difference and variation of this impact under heterogeneous conditions. The model was then combined with the spatial econometric model to explore the effect of the spatial lag factor. The results are as follows: (1) The QSM has unveiled a great improvement space for AEE that remains low overall, despite displaying a rising trend; the highest AEE is in the eastern region. (2) The FUI has a significant negative effect on AEE with the rise in quantiles, this negative effect tended towards weakening overall, although it rebounded slightly; it was stronger in areas with low AEE. It is necessary to consider the heterogeneous conditions in comparison with the average treatment effect of ordinary panel econometric regressions. (3) The impact of FUI shows significant variability in different economic sub-divisions and different sub-periods. (4) After considering the spatial effect of fertilizer use, the negative influence on local AEE had a faster decay rate as the quantile rose, but could produce a positive spatial spillover effect on AEE in neighboring areas. Local governments should dynamically adjust and optimize their fertilizer reduction and efficiency improvement policies according to the level and development stage of their AEE to establish a complete regional linked agroecological cooperation mechanism.

[Progress on research of specificity of acupoint effects during "the 11th five-year"].

With retrieval in CNKI and MEDLINE data base, the articles in Chinese and English that were written by Chinese authors, which were about the specificity of acupoint effects during "the Eleventh Five-Year (2006-2010)", are included. Researchers have studied about the specificity of acupoint effects by cerebral function imaging technique and it turns out that from the perspective of central mechanism, there are differences among aupoint stimulatory effect. The curative effect of acupoints is significantly better than that of nonacupoints, different acupoints have different curative effects, the effect of disease-related acupoints is better than that of unrelated acupoints, those above have intitally proved the existence of specificity of acupoint effects. However, part of the research results need futher summaries, analysis and promotion as well as try to avoid low-level repeat in research design.

One-pot synthesis of substituted furans using Cu(OTf)(2)-catalyzed propargylation/cycloisomerization tandem reaction.

A convenient one-pot propargylation/cycloisomerization tandem process has been developed for the synthesis of substituted furans derivatives from 1,3-dicarbonyl compounds and enoxysilanes with propargylic alcohols or acetates using copper(II) triflate as a bifunctional catalyst. This method provides a flexible and rapid route to substituted furans.

[The reason and management of the sunken upper eyelid after hydroxyapatite platform implantation].

OBJECTIVE: To study the reason and the management of the sunken upper eyelid after implanting a hydroxyapatite platform. METHODS: From 1998, we developed a method of subperiosteal implantation at the orbital floor to repair the introcession of the upper eyelid after hydroxyapatite platform implantation. 11 cases of the sunken upper eyelid were treated with this method. The implants included Medpor in 2 cases, hydroxyapatite plates in 7 cases and acellular dermal matrix in 2 cases. RESULTS: Postoperatively, all the patients obtained satisfactory results. Follow-up for 1 to 4 years showed no complications of extrusion or infection of the implants. Re-operation was needless in all of them. CONCLUSION: Subperiosteal implantation to correct the sunken upper eyelid is a safe and effective method.