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1.
Neuromodulation ; 17(4): 373-79; discussion 380, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23924055

RESUMO

OBJECTIVE: The aims were to investigate the energy-dose response effect of intestinal electrical stimulation (IES) on small bowel motility, to compare the effect of forward and backward IES, and to explore the possibility of using intermittent IES and mechanism of IES on intestinal motility. MATERIALS AND METHODS: Five dogs implanted with a duodenal cannula and one pair of intestinal serosal electrodes were studied in five sessions: 1) energy-dose response study; 2) forward IES; 3) backward IES; 4) intermittent IES vs. continuous IES; 5) administration of guanethidine. The contractile activity and tonic pressure of the small intestine were recorded. The duration of sustained effect after turning off IES was manually calculated. RESULTS: 1) IES with long pulse energy dose dependently inhibited contractile activity and tonic pressure of the small intestine (p < 0.001). 2) The duration of sustained inhibitory effect of IES on the small intestine depended on the energy of IES delivered (p < 0.001). 3) The potency of the inhibitory effect was the same between forward and backward IES. 4) The efficacy of intermittent IES was the same as continuous IES in inhibiting motility of the small intestine. 5) Guanethidine blocked the inhibitory effect of IES on intestinal motility. CONCLUSIONS: IES with long pulses inhibits small intestinal motility; the effect is energy-dose dependent, diffused, and sustained. Intermittent IES has the same efficacy as the continuous IES in inhibiting small intestinal motility. Forward and backward IES have similar inhibitory effects on small bowel motility. This IES-induced inhibitory effect is mediated via the sympathetic pathway.


Assuntos
Fibras Adrenérgicas/fisiologia , Motilidade Gastrointestinal/fisiologia , Intestino Delgado/fisiologia , Inibição Neural/fisiologia , Animais , Cães , Estimulação Elétrica , Feminino , Intestino Delgado/inervação , Contração Muscular/fisiologia , Distribuição Aleatória , Fatores de Tempo
2.
Am J Physiol Regul Integr Comp Physiol ; 296(1): R36-42, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18945955

RESUMO

The aim of this study was to investigate the effects and mechanisms of intestinal electrical stimulation (IES) on gastric tone, antral and pyloric contractions, and gastric emptying in dogs. Female hound dogs were equipped with a duodenal or gastric cannula, and one pair of serosal electrodes was implanted in the small intestine. The study consisted of five different experiments. Liquid gastric emptying was assessed by collection of chyme from the duodenal cannula in a number of sessions with and without IES and with and without N-nitro-l-arginine (l-NNA). Postprandial antral and pyloric contractions were measured with and without IES and in the absence and presence of l-NNA or phentolamine by placement of a manometric catheter into the antrum and pylorus via the duodenal cannula. Gastric tone was assessed by measurement of gastric volume at a constant pressure. Gastric emptying was substantially and significantly delayed by IES or l-NNA compared with the control session. IES-induced delay of gastric emptying became normal with addition of l-NNA. IES reduced gastric tone, which was blocked by l-NNA. IES also inhibited antral contractions (frequency and amplitude), and this inhibitory effect was not blocked by l-NNA but was blocked by phentolamine. IES alone did not affect pyloric tone or resistance, but IES + l-NNA decreased pyloric tone. In conclusion, IES reduces gastric tone via the nitrergic pathway, inhibits antral contractions via the adrenergic pathway, does not affect pyloric tone, and delays liquid gastric emptying. IES-induced delay of gastric emptying is attributed to its inhibitory effects on gastric motility.


Assuntos
Sistema Nervoso Entérico/fisiologia , Esvaziamento Gástrico , Intestinos/inervação , Contração Muscular , Antro Pilórico/inervação , Piloro/inervação , Fibras Adrenérgicas/fisiologia , Antagonistas Adrenérgicos alfa/farmacologia , Animais , Cães , Estimulação Elétrica , Sistema Nervoso Entérico/efeitos dos fármacos , Inibidores Enzimáticos/farmacologia , Feminino , Esvaziamento Gástrico/efeitos dos fármacos , Manometria , Contração Muscular/efeitos dos fármacos , Inibição Neural , Neurônios Nitrérgicos/fisiologia , Óxido Nítrico Sintase/antagonistas & inibidores , Nitroarginina/farmacologia , Fentolamina/farmacologia , Período Pós-Prandial , Pressão , Antro Pilórico/efeitos dos fármacos , Fatores de Tempo
3.
Curr Gastroenterol Rep ; 5(5): 419-24, 2003 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-12959724

RESUMO

Neurostimulation, neosphincters with neurostimulation, and implanted artificial sphincters are recently developed therapeutic options for patients with end-stage fecal incontinence. Of these approaches, sacral nerve electric stimulation appears to be the most promising because of its relative simplicity and low morbidity. However, it is best suited for patients with anatomically intact sphincters. The other procedures target patients with gross structural defects in the sphincter but are still in their infancy. In this article we discuss these techniques and review their rationale, mechanisms of action, indications, outcomes, and complications.


Assuntos
Canal Anal/fisiopatologia , Canal Anal/cirurgia , Procedimentos Cirúrgicos do Sistema Digestório/métodos , Terapia por Estimulação Elétrica/métodos , Incontinência Fecal/cirurgia , Reto/fisiopatologia , Reto/cirurgia , Humanos
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