[CLINICAL AND IMMUNOLOGICAL CRITERIA FOR THE ADVERSE COURSE OF INFECTIOUS MONONUCLEOSIS IN CHILDREN].

The article presents the results of our own studies to determine the criteria for the adverse variants of the course of infectious mononucleosis (IM) in children. The study was conducted in the regional children's infectious clinical hospital in Kharkov. 161 children aged three to fifteen years were under observation with diagnosis of infectious moninucleosis. Out of 161 ill children, 140 (86.9%) had moderate severity of disease, and 21 (13.1%) had severe forms. All children were prescribed standard clinical and laboratory-instrumental examinations. The diagnosis of IM was verified by PCR (detection of VEB DNA in the blood) and ELISA (anti-VEB Ig M and Ig G). In 140 children (86.9%) IM proceeded sharply, smoothly (the first group), in 21 (13.1%) - unfavorably (wave and / or prolonged course) - the second group. The groups were comparable according to age, the severity of the disease and other parameters. All children received therapy according to approved protocols (Order of the Ministry of Health of Ukraine No. 354 of 09.07.2004). Immune status of children was assessed by determining the relative contents of CD3 +, CD4 +, CD8 +, CD16 +, CD19 + blood cells with appropriate monoclonal antibodies, serum IgA, IgM, IgG concentration by Mancini and interleukin (IL) -1ß cytokine response and - 4, tumor necrosis factor (TNF α) is a solid-phase enzyme-linked immunosorbent assay. Based on the results of observations, it was established that the prognostically unfavorable criteria of IМ at the stages of manifestation of disease include: generalized lymphadenopathy involving 5-6 groups of lymph nodes and a significant increasing of them, purulent tonsillitis, marked increasing of size of liver and spleen on the background of anemia, thrombocytopenia, neutropenia and the absence of atypical mononuclears in the complete blood count. There is a depression of the cellular link and an increase in the humoral mechanisms of immune responses in case of development of adverse course of IM.

[Effect of acenocoumarol and aspirin on platelet function, markers of thrombinemia, and intracardiac thrombosis in patients with atrial fibrillation].

Patients with atrial fibrillation taking either indirect anticoagulant acenocumarol or most often prescribed antiaggregant aspirin were followed for 1 year. The results have shown that therapy with acenocumarol lowers content of D-dimer, prevents formation and promotes lysis of left auricular thrombi and lowers risk of development of ischemic stroke in patients with atrial fibrillation and high risk of thromboembolism. Therapy with aspirin in a dose providing maximal suppression of platelet function, does not lower D-dimer levels, does not promote lysis of left auricular thrombi and is inferior to acenocumarol in prevention of ischemic stroke.

[Pharmacotherapy with zaldiar of the pain syndrome in diabetic polyneuropathy].

Zaldiar is a complex medication containing 37,5 mg of tramadol and 325 mg of paracetamol. It has been used in the treatment of 30 patients with diabetes mellitus type II with neurological pain caused by diabetic polyneuropathy. The treatment duration was 10 days with tailored dosages from 1 to 4 tablets. The examination of patients was carried out before the treatment, during it daily and 10 days after. Pain intensity was assessed mainly by the Visual Analogue Scale (VAS). The analgesic effect of zaldiar by VAS was noticed from the 2nd day with the corresponding subjective feeling on the 4th day when the intensity of pain was reduced by 30%. In total, the pain was reduced by 50% in 23 patients and at least by 30% in the others. The drug was well-tolerated.

[Health education in urban pediatric polyclinics]. / Sanitarno-prosvetitel'naia rabota detskikh gorodskikh poliklinik.

The state of health education in city children's polyclinics was analyzed in 7 republics (RSFSR, the Lithuanian, Estonian, Kirghiz, Kazakh, Turkmenian and Azerbaijan SSR) and parents' preparedness to bring up a healthy child was evaluated in children's polyclinics of Moscow, Alma-Ata, Rostov-on-Don and the Rostov Region. 1126 medical workers (chief physicians, sector pediatricians, different specialists) and 435 parents of infants of the first year were interviewed. Unsatisfactory state and insufficient efficacy of health education pertaining to the problems of upbringing a healthy child were pointed out along with the absence of modern scientifically proved programme, methodological materials on health education of the parents with infants, necessary printed and visual materials for parents. The study findings helped to determine ways for further improvement of health education and family training at city children's polyclinics.