RESUMO
To provide diagnosis of recurrent herpetic stomatitis (RHS), non-direct immunoperoxidase (IP) and immunofluorescent (IF) methods were used, and to assess the immunoreactivity--complement fixation reaction (CFR), lymphocyte blasttransformation reaction (LBTR) as well as the passive hemagglutination reaction (PHR). A total of 21 patients with clinically assessed diagnosis of RHS was examined. The IP method obtained results were compared with those obtained with use of IF method. In both used diagnostical tests, the IP method was proved as giving more positive findings at oral mucosa samples examination. The titres of antibodies to Herpes simplex virus showed variability as follows: from 1:4 to 1:320 in CFR and from 1:10 to 1:160 in PHR. The immunity status assessment using LBTR pointed on a decrease of general immunoreactivity of patients with RHS.
Assuntos
Estomatite Herpética/imunologia , Adulto , Testes de Fixação de Complemento , Feminino , Imunofluorescência , Testes de Hemaglutinação , Humanos , Técnicas Imunoenzimáticas , Ativação Linfocitária , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/imunologia , Recidiva , Estomatite Herpética/diagnósticoRESUMO
Of 27 aryl-furfurane derivatives (AFD) studied, 13 compounds were found to have antiviral activity against ECHO 6, herpes simplex, vaccinia, and influenza A/Hong Kong/1/68 (H3N2) viruses, the highest inhibition being observed with ECHO 6 virus. The maximum tolerated concentrations (MaTC) of AFD inhibited the macromolecular syntheses in ECHO 6 virus-infected cell cultures.
