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Objective To explore the mediating effect of self-management behavior between nervous functional defects and health condition in patients with stroke.Methods A total of 100 patients with stroke chosen in Jianhu hospital affiliated to Nantong University from March to June 2015 were investigated using SSMBS,SSS and SRHMS through questionnaires after they left hospital for one year.The data was analyzed by stepwise regression analysis and Bootstrap procedure via SPSS13.0 and AMOS7.0.Results The total scores of SSS,SSMBS and SRHMS were (13.38±5.29),(162.59±21.43) and (278.13±51.48),respectively.Bivariate correlation analysis showed that there were correlations among self-management behavior,neurological impairment and self-rating health (r=-0.735,-0.568,0.693,P<0.01).The value of the mediating effect of self-management behavior was 0.137,accounting for 24.1% of the total effect.Bootstrap test showed 95% confidence interval of the direct mediating effect of self-management behavior was (0.006,0.208).Conclusions elf-management behavior has stronger mediating effect between nervous functional defects and health condition,it is a predictive factor of nervous functional defects and health condition.Medical workers should enhance the intervention of health self-management behavior for the patients with chronic diseases such as stroke.
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<p><b>OBJECTIVE</b>By bioinformatics method, the effect in hematopoietic system of bioactive peptide HP-6, which was obtained from donkey serum albumin and is one of the major protein components from donkey-hide gelatin, was investigated.</p><p><b>METHOD</b>Human bone marrow nucleated cells (hBMNCs) and murine bone marrow stromal cells (mBMSCs) were separated and cultured with different concentration of peptide HP-6 (0.000 15, 0.001 5, 0.015, 0.15, 1.5 micromol x L(-1)). The effect on promoting proliferation of cells related to hematopoiesis in bone morrow was detected and the ultrastructure of cells after treated by HP-6 was observed through transmission electron microscope. Hemorrhage anemia mouse model and anemia mouse model induced by cyclophosphamide were established, and randomly divided into peptide HP-6 groups which were administered respectively with different doses (1, 0.1, 0.01 mg x kg(-1)) by gavage, and control group which was administered with PBS by gavage. Peripheral blood components of all mice and bone morrow cells (BMC) number of mice induced by cyclophosphamide were evaluated.</p><p><b>RESULT</b>Peptide HP-6 could concentration-related promote the proliferation of hBMNCs and mBMSCs, hBMNCs got the highest reproduction rate of 152.11% and mBMSCs also got 63.52% with the concentration of 0.15 micromol x L(-1), then the reproduction rate decreased while the concentration kept increasing. The transmission electron microscope showed that ultrastructure of cells was normal after treated by HP-6.1 mg x kg(-1) peptide HP-6 significantly increased peripheral platelet and protected mouse morrow injured by cyclophoshamide. 0.1 mg x kg(-1) peptide HP-6 significantly increased peripheral platelet with relative growth rate of 77.65%, increased peripheral white blood cells count and peripheral red blood cells count, also could protect mouse peripheral blood after treated by chemotherapeutics.</p><p><b>CONCLUSION</b>Peptide HP-6 could promote the proliferation of cells related to hematopoietic system, enhance mouse hemopoiesis function and the resistance to chemotherapeutic injury.</p>
