1.
J Org Chem
; 88(6): 3859-3870, 2023 Mar 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36827631
RESUMO
CF3-cyclopropanes with aliphatic, aromatic, and even heteroaromatic substituents were prepared on a multigram scale by deoxyfluorination of cyclopropane carboxylic acids or their salts with sulfur tetrafluoride. For labile α-pyridine acetic acids, only the use of their potassium salts allowed to obtain the needed products. Derivatization of CF3-cyclopropanes into building blocks ready for direct use in medicinal chemistry was performed.