RESUMO
Recurrence risks of cancer patient can change during treatment as a result of treatment-related tumor evolution. However, biomarkers that can monitor these changes are lacking. Here, we investigated whether tracking circulating tumor DNA (ctDNA) dynamics through liquid biopsy can inform real-time recurrence risk. Nasopharyngeal carcinoma (NPC) provides an ideal model where cell-free Epstein-Barr virus (EBV) DNA (cfEBV DNA), a ctDNA, can be sensitively detected. We conducted the EP-SEASON study (NCT03855020) and prospectively recruited 1,000 NPC patients undergoing per-protocol cfEBV DNA assessments at 11 time points and receiving sequential chemo-radiotherapy. Longitudinal cfEBV DNA displayed distinct patterns during neoadjuvant chemotherapy and radiotherapy. Despite the prognostic significance of cfEBV DNA at each time point, real-time recurrence risks changed in sync with cfEBV DNA dynamics. Furthermore, we identified phenotypes of whole-course ctDNA changing dynamics associated with different survival outcomes. In conclusion, tracking longitudinal on-treatment ctDNA can forecast real-time recurrence risk, facilitating risk-adapted, individualized patient management.
RESUMO
PURPOSE: To study the height of alveolar ridge and the distance between the wall of maxillary sinus on the curve of the dental arch, and to explore the guiding significance for maxillary sinus surgery and edentulous jaw implant surgery. METHODS: Cone-beam CT(CBCT) data of 105 objects were selected to measure the height of alveolar ridge and the maximum bone internal distance between the wall of maxillary sinus 10 mm and 12 mm above the alveolar crest horizontally on the curve of the dental arch. Forty-nine objects with alveolar ridge height on the molar area less than or equal to 10 mm were included for further investigation. The distance between the maxillary sinus wall, and the angle between the maxillary sinus wall on the horizontal plane were measured and calculated. SPSS 22.0 software package was used for statistical analysis of the data. RESULTS: The mean value of the alveolar ridge height in the posterior teeth area was first premolar > second premolars > second molars > first molars. The mean value of the horizontal distance between the wall of sinus 10 mm and 12 mm above the alveolar crest horizontally was (82.40±27.56) mm and (70.54±29.70) mm in 105 objects, while (67.85±28.53) mm and (52.75±24.90) mm in 49 included objects, respectively. The mean value of the angle between the maxillary sinus wall on the horizontal plane was (23.55±39.13)°. There was no significant difference between males and females. However, the horizontal distance had statistically significant differences between different groups and in different horizontal levels of the same group. CONCLUSIONS: CBCT is helpful to establish implant surgical plan, and carry out maxillary sinus lift and edentulous jaw implant surgery.
