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Bioorg Med Chem Lett
; 21(10): 3074-7, 2011 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21486694
RESUMO
Three series of butenolide-containing dithiocarbamates were designed and synthesized. Their anti-tumor activity in vitro was evaluated. Among them compound I-14 exhibited broad spectrum anti-cancer activity against five human cancer cell lines with IC(50) <30 µM. Structure-activity relationship analysis showed that the introduction of dithiocarbamate side chains on the C-3 position of butenolide was crucial for anti-tumor activity.