Modulating confinement space in metal-organic frameworks enables highly selective indole C3-formylation.

Here, Selective C3-formylation of indole was achieved under mild conditions using a metal-organic framework (MOF) catalyst. The confined reaction space within the MOF pores effectively suppressed undesired side reactions and promoted the formation of the targeted product by controlling the reaction pathway. Density functional theory (DFT) calculations corroborated the experimental observations.

High Catalytic Activity of C60 Pdn Encapsulated in Metal-Organic Framework UiO-67, for Tandem Hydrogenation Reaction.

Metal nanoparticles (NPs) stabilized by MOFs are very promising for catalysis, whereas introduction of C60 into MOFs has been very rarely used, and there was no report for their cooperative catalysis in organic syntheses. In this work, C60 @UiO-67 was synthesized by a one-pot method, so that C60 is uniformly distributed on UiO-67 in molecular form. Pd NPs coordinating with C60 have been successfully embedded into the framework. The obtained multifunctional C60 Pdn @UiO-67 catalyst exhibits remarkable synergistic catalytic activity in cascade reactions under mild conditions, where UiO-67 affords Lewis acidity and C60 Pdn offers higher hydrogenation activity relative to solely Pd NPs.