Attribute latencies causally shape intertemporal decisions.

Intertemporal choices - decisions that play out over time - pervade our life. Thus, how people make intertemporal choices is a fundamental question. Here, we investigate the role of attribute latency (the time between when people start to process different attributes) in shaping intertemporal preferences using five experiments with choices between smaller-sooner and larger-later rewards. In the first experiment, we identify attribute latencies using mouse-trajectories and find that they predict individual differences in choices, response times, and changes across time constraints. In the other four experiments we test the causal link from attribute latencies to choice, staggering the display of the attributes. This changes attribute latencies and intertemporal preferences. Displaying the amount information first makes people more patient, while displaying time information first does the opposite. These findings highlight the importance of intra-choice dynamics in shaping intertemporal choices and suggest that manipulating attribute latency may be a useful technique for nudging.

When the Counterpart Chooses the Opposite: The First Mover's Anticipation and Evaluation of the Final Feedback in Gambles.

This research examines the effect of response (in)consistency on the first mover's anticipation and evaluation of the performance feedback in gambles. In a two-player gambling task, the participant played as the first mover while the confederate served as the second mover, who made their gambles in sequence. A more pronounced feedback-related negativity (FRN) was observed when the first mover noticed that the second mover chose a different option from him/her. An enlarged stimulus-preceding negativity (SPN) was observed when the first mover was anticipating the final feedback in this condition. Interestingly, consistent responses gave rise to a more pronounced FRN difference wave (d-FRN) during the feedback stage. Taken together, these results suggest that response discrepancy would modulate the first mover's anticipation and evaluation of the final feedback in gambles.

The Effect of Safety Signs on the Monitoring of Conflict and Erroneous Response.

The safety sign is important in our daily life and workplace to prevent potential safety issues. However, it remains undetermined whether the safety signs would influence the cognitive control ability of the people, which serves to guide the behaviors in a goal-directed manner. Therefore, this study aimed to examine the effect of safety signs on cognitive control by uncovering the behavioral performance and neural manifestations underlying the monitoring of conflict and error. The participants performed a flanker task after watching low- and high-hazard safety signs with the electroencephalogram (EEG) data recorded continually. The behavioral results indicated a classic congruency effect with higher accuracy rate and faster response time under a congruent condition compared to an incongruent condition. However, no hazard effect on behavioral performances was observed. The results of event-related potentials (ERPs) demonstrated a more negative N2 elicited by the incongruent trials and an increased (error-related negativity) ERN difference between the error and correct responses in the high-hazard condition compared to those in the low-hazard condition, implying that the monitoring of the conflict and error were both enhanced after watching the high-hazard safety signs. This study contributes to the understanding of the relationship between safety signs and cognitive control, and further expand the measurements that can be applied to assess the effectiveness of safety signs design.

Confidence Modulates the Conformity Behavior of the Investors and Neural Responses of Social Influence in Crowdfunding.

The decision about whether to invest can be affected by the choices or opinions of others known as a form of social influence. People make decisions with fluctuating confidence, which plays an important role in the decision process. However, it remains a fair amount of confusion regarding the effect of confidence on the social influence as well as the underlying neural mechanism. The current study applied a willingness-to-invest task with the event-related potentials method to examine the behavioral and neural manifestations of social influence and its interaction with confidence in the context of crowdfunding investment. The behavioral results demonstrate that the conformity tendency of the people increased when their willingness-to-invest deviated far from the group. Besides, when the people felt less confident about their initial judgment, they were more likely to follow the herd. In conjunction with the behavioral findings, the neural results of the social information processing indicate different susceptibilities to small and big conflicts between the own willingness of the people and the group, with small conflict evoked less negative feedback-related negativity (FRN) and more positive late positive potential (LPP). Moreover, confidence only modulated the later neural processing by eliciting larger LPP in the low confidence, implying more reliance on social information. These results corroborate previous findings regarding the conformity effect and its neural mechanism in investment decision and meanwhile extend the existing works of literature through providing behavioral and neural evidence to the effect of confidence on the social influence in the crowdfunding marketplace.

To run with the herd or not: Electrophysiological dynamics are associated with preference change in crowdfunding.

The herd instinct is a common feature of human society and is frequently encountered in a myriad of other human social interaction including entertainment, fashion, and the adoption of new gadgets. Indeed, social influence, taking account of others' actions in one's decisions, is ubiquitous in our daily life. With the growing prevalence of crowdfunding investments, an increasing number of studies are currently focused on how social influences impact such behavior. Moreover, only a few studies have examined its neural correlates and the value of evaluating social influence as a possible predictor of herd behavior especially regarding crowdfunding. The present study aims to parse the neural processing of social influences on crowdfunding investment and examine whether neural signals can be correlated with an individuals' willingness to invest. Our results demonstrate that the greater ones' choice deviates from the overall group judgement, there is a resulting increased deflection of the feedback related negativity (FRN). However, the averaged and single trial analysis reveal that the subsequent P300, rather than the feedback related negativity, reflects the magnitude of social influence on individual behavior. Single trial analysis of the EEG data shows that, in addition to the behavioral manipulation, the deflection of the P300 is a robust signal, which is associated with the behavioral adjustment following an individual's awareness of the group opinion at the trial-by-trial level. The current study freshly extends the growing literature on social influences on decision making stemming from another's action to the new investment possibilities of crowdfunding investment and notably observes that the P300 component at the outcome stage evidently is associated with the behavioral-decision making shift evoked by following the herd.

Effort provides its own reward: endeavors reinforce subjective expectation and evaluation of task performance.

Although many studies have investigated the relationship between the amount of effort invested in a certain task and one's attitude towards the subsequent reward, whether exerted effort would impact one's expectation and evaluation of performance feedback itself still remains to be examined. In the present study, two types of calculation tasks that varied in the required effort were adopted, and we resorted to electroencephalography to probe the temporal dynamics of how exerted effort would affect one's anticipation and evaluation of performance feedback. In the high-effort condition, a more salient stimulus-preceding negativity was detected during the anticipation stage, which was accompanied with a more salient FRN/P300 complex (a more positive P300 and a less negative feedback-related negativity) in response to positive outcomes in the evaluation stage. These results suggested that when more effort was invested, an enhanced anticipatory attention would be paid toward one's task performance feedback and that positive outcomes would be subjectively valued to a greater extent.

Close games versus blowouts: Optimal challenge reinforces one's intrinsic motivation to win.

When immersed in intrinsically motivating activities, individuals actively seek optimal challenge, which generally brings the most satisfaction as they play hard and finally win. To better simulate real-life scenarios in the controlled laboratory setting, a two-player online StopWatch (SW) game was developed, whose format is similar to that of a badminton tournament. During the game, a male opponent played by a confederate ensured that the same-sex participant paired with him won both matches, one with a wide margin (the lack of challenge condition) and another with a narrow one (the optimal challenge condition). Electrophysiological data were recorded during the entire experiment. An enlarged Stimulus-preceding negativity (SPN) was observed in the optimal challenge condition, indicating a more concentrated anticipatory attention toward the feedback and a stronger intrinsic motivation during close games. Thus, this study provided original neural evidence for predictions of Self-determination theory (SDT) and Flow theory, and confirmed and emphasized the significant role of optimal challenge in promoting one's intrinsic motivation to win.

Ingroup favoritism or the black sheep effect: Perceived intentions modulate subjective responses to aggressive interactions.

Social categorization plays an important role in provoking the victim's responses to aggressive interactions. Pioneering studies suggested that uncertainty in the perpetrator's hostile intention influences whether ingroup favoritism or the black sheep effect (ingroup strictness) will be manifested to a greater extent. However, when the hostile intention is ambiguous, subjective perception of the perpetrator's intention may still be quite different due to the inherent information gap between participants, and this discrepancy in perceived intentions may further modulate subjective responses to social aggression. In the present study, subjects played as responders of the Ultimatum Game, and received varied offers proposed by either ingroup or outgroup members. Electrophysiological results showed that, when proposers were perceived to be intentional, unfair offers from ingroups elicited significantly larger Feedback-related Negativity (FRN) than those from outgroups, potentially providing neural evidence for the black sheep effect. The opposite FRN pattern was observed when proposers were perceived to be unintentional, which might suggest ingroup favoritism. Interestingly, despite contrary neural patterns, perceived intentions did not modulate behavioral response to aggressive interactions. Thus, converging results suggested that, when the perpetrator's hostile intention remained ambiguous, perceived intentions modulated the victim's electrophysiological response while not the rational behavioral response to aggressive interactions.

P300 and Decision Making under Risk and Ambiguity.

Our study aims to contrast the neural temporal features of early stage of decision making in the context of risk and ambiguity. In monetary gambles under ambiguous or risky conditions, 12 participants were asked to make a decision to bet or not, with the event-related potentials (ERPs) recorded meantime. The proportion of choosing to bet in ambiguous condition was significantly lower than that in risky condition. An ERP component identified as P300 was found. The P300 amplitude elicited in risky condition was significantly larger than that in ambiguous condition. The lower bet rate in ambiguous condition and the smaller P300 amplitude elicited by ambiguous stimuli revealed that people showed much more aversion in the ambiguous condition than in the risky condition. The ERP results may suggest that decision making under ambiguity occupies higher working memory and recalls more past experience while decision making under risk mainly mobilizes attentional resources to calculate current information. These findings extended the current understanding of underlying mechanism for early assessment stage of decision making and explored the difference between the decision making under risk and ambiguity.

[Generation and characterization of the adult neuron-specific ADAM10 knock-out mice].

A disintegrin and metalloproteinase 10 (ADAM10) is a major sheddase for over 30 different membrane proteins and gets involved in such physiological processes and pathogenesis as embryonic development, cell adhesion, signal transduction, immune reaction, cancer, and Alzheimer's disease. Both ADAM10 knock-out mice and the neural progenitor cell-specific ADAM10 knock-out mice having been reported so far died in the embryonic or perinatal stage, respectively, thus resulting in the failure to investigate ADAM10 function in the adult mouse brain. Through a series of tests, we have succeeded in generating and characterizing the CaMKIIα-Cre/ADAM10(loxP/loxP) mice surviving until adulthood by means of crossing ADAM10(loxP/loxP) mice with newly generated CaMKIIα-Cre transgenic mice. PCR analysis of genomic DNAs from different regions of the ADAM10 cKO mouse brain shows that the deleted ADAM10 alleles are mainly found in the cortex and hippocampus. Real-time RT-PCR findings further confirm that ADAM10 mRNAs decrease in the cortex and hippocampus by 55.7% and 60.8%, respectively. Western-blotting analysis demonstrates 63% and 84.8% loss of mature ADAM10 proteins from the cortex and hippocampus. Immunohistochemical tests show that there is significantly less ADAM10- positive staining in the cortical and hippocampal neurons but not gliocytes of ADAM10 cKO mice compared with control mice. In summary, we established the adult neuron-specific ADAM10 knock-out (cKO) mice for the first time, which prevented ADAM10(-/-) mice from the embryonic and perinatal mortality and laid a firm foundation for the further study of ADAM10 function in the brain of adult mice in vivo.