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Org Lett ; 24(30): 5557-5561, 2022 08 05.
Artigo em Inglês | MEDLINE | ID: mdl-35867631

RESUMO

An efficient method for the synthesis of ß,ß-di(hetero)aryl-α,α-difluorinated ketones using readily available organophosphonium salts and difluoroenol silyl ethers has been developed. This mild reaction features a good functional group tolerance, a scaled-up synthesis, and synthetic simplicity. By taking advantage of DMSO as a less-toxic promoter and solvent for the difluoroalkylation and C-P bond functionalization, the use of transition-metal catalysts and sensitive additives could be avoided.


Assuntos
Éteres , Sais , Catálise , Dimetil Sulfóxido , Éteres/química , Cetonas/química
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