Analysis and prospect of potential value of fecal microbiota transplantation in the treatment of short bowel syndrome / 中国综合临床

Short bowel syndrome (SBS) is a series of clinical syndromes caused by the reduction of effective functional area of small intestine for different reasons.Due to the changes of intestinal function and internal environment, SBS can further lead to intestinal mucosal barrier damage, enterogenous liver damage, abnormal bile acid metabolism and so on, which seriously affects the clinical outcome and prognosis of patients. Fecal microbiota transplantation is the transplantation of normal functional bacteria in feces into patients' intestines to help restore and rebuild the balance of intestinal flora. It has been successfully used in the treatment of intestinal and extraintestinal diseases. This paper reviews and prospects the potential value of fecal bacteria transplantation in the treatment of SBS for D-lactic acidosis, intestinal rehabilitation and liver damage associated with intestinal failure, in order to provide new clinical ideas for the treatment of SBS patients.

Evidence for gastrointestinal infection of SARS-CoV-2

The new coronavirus (SARS-CoV-2) outbreak originating from Wuhan, China, poses a threat to global health. While its evident that the virus invades respiratory tract and transmits from human to human through airway, other viral tropisms and transmission routes remain unknown. We tested viral RNA in stool from 73 SARS-CoV-2-infected hospitalized patients using rRT-PCR. 53.42% of the patients tested positive in stool. 23.29% of the patients remained positive in feces even after the viral RNA decreased to undetectable level in respiratory tract. The viral RNA was also detected in gastrointestinal tissues. Furthermore, gastric, duodenal and rectal epithelia showed positive immunofluorescent staining of viral host receptor ACE2 and viral nucleocapsid protein in a case of SARS-CoV-2 infection. Our results provide evidence for gastrointestinal infection of SARS-CoV-2, highlighting its potential fecal-oral transmission route.

Fulminant type 1 diabetes mellitus associated with special populations / 中国医师杂志

Fulminant type 1 diabetes (FT1D) is a new subtype of type 1 diabetes mellitus.It has a fulminant onset of symptoms accompanied with disturbance of consciousness or elevated trypsin,severe hyperglycemia,and severe metabolic disorders.It is a critical disease.FT1D in pregnant women,the elderly,and children and adolescents have different clinical manifestations and treatments due to their different physiological aspects in comparison with that in the adults.This article summarizes the characteristics and managements of FT1D in pregnant women,the elderly,and children and adolescents in order to further enhance the understanding of FT1 D.We call on all clinicians to be vigilant and pay attention to the early diagnosis and treatment of FT1 D in special populations.

Roles of ambulatory blood pressure monitoring in the prediction of outcome in patients w ith acute ischemic stroke / 国际脑血管病杂志

Inrecentyears,somecardiovascularguidelineshavegradualyintroducedambulatory blood pressure monitoring ( ABPM ) as an indispensable means for better diagnosis and management of hypertensive patients. ABPM can more comprehensively provide 3 types of information that has potential clinical value:the assessment of real or mean blood pressure level, the diurnal rhythm of blood pressure, and the blood pressure variability. This article review s the roles of ABPM in the outcome assessment in patients w ith acute ischemic stroke.