RESUMO
Effects of dehydroepiandrosteron sulfate on oxidative stress- and ethanol-induced morphological changes and level of apoptotic enzymes (Bcl-2 and caspase-3) of lymphocytes in healthy persons have been studied. This study showed that hydroperoxide induces apoptotic changes in lymphocytes. Ethanol did not change the basal concentration of apoptotic enzyme. Dehydroepiandrosteron sulfate prevented the augmentation of apoptosis in hydroperoxide-treated lymphocytes.
Assuntos
Apoptose/efeitos dos fármacos , Sulfato de Desidroepiandrosterona/farmacologia , Linfócitos/metabolismo , Estresse Oxidativo/efeitos dos fármacos , Adulto , Caspase 3/metabolismo , Etanol/farmacologia , Feminino , Humanos , Linfócitos/citologia , Masculino , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Solventes/farmacologiaRESUMO
Spontaneous and induced apoptosis of neutrophils and lymphocytes was studied in alcoholics during the abstinent syndrome and in healthy individuals. In alcoholics, the levels of lymphocyte and neutrophil apoptosis at the receptor and cellular levels were higher than in healthy subjects. Blood cells from alcohol addicts and normal individuals similarly react to stimuli (hyperthermia and synthetic glucocorticoid prednisolone) in vitro.
