[Role of S. S. Iudin in the development of emergency anesthesiology at the Moscow Sklifosovskii Research Institute of Emergency Care]. / Rol' S. S. Iudina v stanovlenii ékstrennoi anesteziologii v Moskovskom NII skoroi pomoshchi im. N. V. Sklifosovskogo.

S. S. Yudin was concerned about the problems of anesthesia from as early as the twenties. Under the term "anesthesia" he combined a whole complex of measures including preoperative management, the production of insensibility to pain, and intraoperative treatment and supported in this manner the creation of anesthesiological care, which was organized at the Sklifosovsky Research Institute of Emergency Care in 1959. The object of all practical and scientific activity of the care was the creation of simple, popular, and effective variants of anesthesia with consideration for the variety of pathophysiological responses. The principal responses are shock, hypovolemia, insufficiency of respiration and gas exchange, inversion of metabolism, intoxication, intracranial hypertension, the compression-dislocation syndrome, and hepatorenal failure. Study of the effect of anesthetics on various organs and systems of the organism made it possible to determine the tactics and methods of anaesthesia for patients with trauma and diseases of the abdominal and thoracic organs, central nervous system, and locomotor apparatus.

[Effect of acute hypoxia on the indices of kidney excretory function and renal hemodynamics]. / Vliianie ostroi gipoksii na nekotorye pokazateli vydelitel'noi funktsii pochek i pochechnoi gemodinamiki.

Diuresis, glomerular filtration, tubular reabsorption (endogenous creatinine clearance), renal blood and plasma flow, total resistance of renal vessels, and filtration fraction were measured in 59 patients with mechanical (strangulation) asphyxia. Asphyxia and resulting hypoxia induced a substantial increase of diuresis, glomerular filtration and a decrease of tubular reabsorption. Disorders of renal hemodynamics which involved a decrease of renal plasma and blood flow and an increase of total resistance of renal vessels contributed significantly to the mechanism of changes of the renal excretory function. As shown by vasographic and morphological examinations, the state of intrarenal hemodynamics plays the major role in changes of the renal function.